2-Methoxyestradiol - Wikipedia
网页2-Methoxyestradiol (2-ME2, 2-MeO-E2) is a natural metabolite of estradiol and 2-hydroxyestradiol (2-OHE2). It is specifically the 2- methyl ether of 2-hydroxyestradiol. 2-Methoxyestradiol prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor. [1] .
2-Methoxyestradiol (2-ME2，二甲氧基雌二醇) - MCE-生物活性 ...
网页2019年8月7日 · 2-Methoxyestradiol (2-ME2)，具有口服活性的 17β-雌二醇 (E2) 的内源性代谢产物，是凋亡 (apoptosis) 诱导剂和血管生成 (angiogenesis) 抑制剂，具有有效的抗肿瘤活性。 2-Methoxyestradiol 也可破坏微管 (microtubules) 的稳定。 2-Methoxyestradiol 是一种有效的超氧化物歧化酶 (SOD) 抑制剂和活性氧生成剂，可诱导转化细胞系 HEK293、癌细胞系 U87 和 HeLa 的自噬 (autophagy)。 MCE 的所有产品仅用作科学研究或药证申报，我们不 …
2-Methoxyestradiol - DrugBank Online
网页2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Type.
2-Methoxyestradiol (2-MeOE2) | 2-甲氧雌二醇 | 购买HIF 抑制剂
网页2-Methoxyestradiol (2-MeOE2, NSC 659853, NSC 659853, 2-ME2) 使微管解聚，并抑制 HIF-1α 核积累以及HIF转录活性。. 2-Methoxyestradiol 可在多种致癌细胞系中诱导自噬和凋亡。. 2-Methoxyestradiol (2-MeOE2) Chemical Structure. CAS: 362-07-2. 规格.
2-Methoxyestradiol | C19H26O3 | CID 66414 - PubChem
网页2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
Anticancer agent 2-methoxyestradiol improves survival in ... - PubMed
网页Cytokine production is critical in sepsis. 2-Methoxyestradiol (2ME2), an endogenous metabolite of estradiol, inhibits hypoxia-inducible factor 1α (HIF-1α) and is an antiangiogenic and antitumor agent. We investigated the effect of …
2-Methoxyestradiol | 362-07-2 | 美国AbMole | 2ME2
网页2-Methoxyestradiol (2-MeOE2)使微管解聚，且抑制HIF-1α核积累和HIF转录活性。. 2-Methoxyestradiol作用于乳腺癌细胞系 MDA-MB-435和卵巢癌细胞系SK-OV-3，抑制细胞增殖，IC50分别为 1.38 μM 和 1.79 μM。而且, 2-Methoxyestradiol作用于大鼠主动脉平滑肌A-10细胞，也抑制细胞微管解聚，EC50 ...
2-Methoxyestradiol protects against IgG immune complex …
网页2017年5月1日 · This article reports that 2-Methoxyestradiol (2ME2), a metabolite of estradiol, protects against IgG immune complex (IC)-induced acute lung injury (ALI) by blocking NF-κB and C/EBPβ activities in macrophages. The study also reveals the involvement of MAPKs and STAT3 in the regulation of inflammatory mediator production and cell infiltration in ALI.
A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal ... - PubMed
网页Purpose: 2ME2 (Panzem®) is a non-estrogenic derivative of estradiol with antiproliferative and antiangiogenic activity. Preclinical data support antitumor activity in prostate cancer. This trial evaluated the efficacy of 2ME2 NCD in …
2ME2 inhibits tumor growth and angiogenesis by ... - ScienceDirect
网页2003年4月1日 · 2ME2 is a well-tolerated orally active small molecule with antiangiogenic and antitumor activity currently in phase I/II clinical trials whose exact mechanism of action is not known. Herein, we report on a novel mechanism mediating the antitumor and antiangiogenic activity of 2ME2.
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