「帕金森动物模型」建立方法详解总结，来看看究竟有哪些？ - 知乎
6-羟多巴胺（6-hydroxydopamine，6-OHDA）是多巴胺的羟基化衍生物，因其化学结构与DA类似，因此能够同DA竞争摄取位点，进而被摄入胞内。. 进入胞内后，6-OHDA能够被氧化分解，产生活性氧，通过MAO（单胺氧化酶）进一步产生氧自由基，或直接引起线粒体功能障碍 ...
Oxidopamine - Wikipedia
Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a synthetic monoaminergic neurotoxin used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain.
Oxidopamine hydrochloride (6-Hydroxydopamine Hydrochloride，6 …
Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE 2 synthesis and pro-inflammatory cytokine IL-1β secretion.
羟多巴胺 - 维基百科，自由的百科全书
羟多巴胺（英语： Oxidopamine ，也称为6-羟基多巴胺，6-hydroxydopamine，缩写6-OHDA，或2,4,5-三羟基苯乙胺，2,4,5-trihydroxyphenethylamine）是一种人工合成的神经毒素，分子式C 8 H 11 NO 3 ，用于在帕金森氏症的研究中破环大脑中的某些特定神经元 [1] 。
6-Hydroxydopamine: a far from simple neurotoxin - PubMed
6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species.
6-OHDA诱导帕金森病模型小鼠多巴胺能神经元坏死性凋亡的可能 …
2023年11月22日 · 有研究报道,necrostatin-1可以有效抑制6-OHDA诱导的PC12细胞死亡 ,提示坏死性凋亡可能参与了6-OHDA对细胞的毒性作用。本研究旨探讨6-OHDA通过调控FADD-RIPK1坏死性凋亡信号通路促进PD模型小鼠DA能神经元变性死亡的可能机制。
6-Hydroxydopamine: a far from simple neurotoxin
2020年1月1日 · 6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson’s disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species.
The 6-hydroxydopamine model of Parkinson's disease - PubMed
The neurotoxin 6-hydroxydopamine (6-OHDA) continues to constitute a valuable topical tool used chiefly in modeling Parkinson's disease in the rat. The classical method of intracerebral infusion of 6-OHDA involving a massive destruction of nigrostriatal dopaminergic neurons, is …
A Guide to the Generation of a 6-Hydroxydopamine Mouse Model …
6-hydroxydopamine (6-OHDA) was identified more than 50 years ago as a catecholamine selective neurotoxin [9,10] and is still widely used to reproduce PD [2,11,12]. The dopamine and noradrenaline transporters mediate the intracellular accumulation of 6-OHDA [ 13 ], which leads to neuronal death through a combination of oxidative stress-induced ...
The Neuro-Protective Effects of the TSPO Ligands CB86 and CB204 on 6 ...
Abstract Simple Summary. Aims and objectives: For this study, we hypothesized that the two TSPO ligands CB86 and CB204 can inhibit cellular apoptosis and necrosis by in in vitro cellular PD model of undifferentiated PC12 cells exposed to 6-hydroxydopamine (6-OHDA, 80 µM). The two TSPO ligands CB86 and CB204 seem to suppress cell death of PC12 induced by 6-OHDA.