7-Dehydrocholesterol - Wikipedia
7-Dehydrocholesterol (7-DHC) is a zoosterol that functions in the serum as a cholesterol precursor, and is photochemically converted to vitamin D 3 in the skin, therefore functioning as provitamin-D 3.
7-Dehydrocholesterol dictates ferroptosis sensitivity | Nature
2024年1月31日 · Nature - 7-Dehydrocholesterol (7-DHC) is a natural anti-ferroptotic metabolite and pharmacological manipulation of 7-DHC levels shows promise as a therapeutic strategy for cancer and...
Vitamin D: Production, Metabolism and Mechanisms of Action
2021年12月31日 · Vitamin D 3 is produced in the skin from 7-dehydrocholesterol by UV irradiation, which breaks the B ring to form pre-D 3. Pre-D 3 isomerizes to D 3 but with continued UV irradiation to tachysterol and lumisterol.
Smith-Lemli-Opitz Syndrome - GeneReviews® - NCBI Bookshelf
1998年11月13日 · Smith-Lemli-Opitz syndrome (SLOS) is a congenital multiple-anomaly / cognitive impairment syndrome caused by an abnormality in cholesterol metabolism resulting from deficiency of the enzyme 7-dehydrocholesterol (7-DHC) reductase.
New aspects of vitamin D metabolism and action - Nature
2020年2月6日 · 7-Dehydrocholesterol reductase (DHCR7). This enzyme converts the substrate for vitamin D formation (7-dehydrocholesterol) to cholesterol.
7 Dehydrocholesterol - an overview | ScienceDirect Topics
7-Dehydrocholesterol is a precursor of cholesterol that can be elevated in certain syndromes like SLOS. It is best assayed using gas chromatography mass spectrometry to distinguish it from other cholesterol precursors.
7 Dehydrocholesterol - an overview | ScienceDirect Topics
The DHCR-7 gene encodes the enzyme 7-dehydrocholesterol reductase which converts 7-dehydrocholesterol to cholesterol. 7-dehydrocholesterol is also the precursor to vitamin D produced via UVB exposure. High levels of 7-dehydrocholesterol reductase may results in low vitamin D levels as 7-dehydrocholesterol is preferentially converted to cholesterol.
7-Dehydrocholesterol | C27H44O | CID 439423 - PubChem
7-Dehydrocholesterol | C27H44O | CID 439423 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Vitamin D and your health: Breaking old rules, raising new hopes
2021年9月13日 · Vitamin D is not one chemical but many. The natural type is produced in the skin from a universally present form of cholesterol, 7-dehydrocholesterol. Sunlight is the key: Its ultraviolet B (UVB) energy converts the precursor to vitamin D 3.
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
2024年1月31日 · Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC).