Aquaporin-3 in the epidermis: more than skin deep
2020年5月28日 · Accumulating evidence in the literature indicates that the water-, glycerol-, and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases.
AQP3 Gene - GeneCards | AQP3 Protein | AQP3 Antibody
2024年10月1日 · AQP3 (Aquaporin 3 (Gill Blood Group)) is a Protein Coding gene. Diseases associated with AQP3 include Oligohydramnios and Nephrogenic Diabetes Insipidus. Among its related pathways are Aquaporin-mediated transport and Developmental Cell Lineages.
Identification and characterization of potent and selective …
Aquaporin-3 (AQP3) has an important physiological function in renal water reabsorption, and AQP3-mediated hydrogen peroxide (H 2 O 2) permeability can enhance cytokine signaling in several cell types. The related aquaglyceroporin AQP7 is required for dendritic cell chemokine responses and antigen uptake.
Aquaporin-3 in the epidermis: more than skin deep - PubMed
2020年6月1日 · Accumulating evidence in the literature indicates that the water-, glycerol-, and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases.
Inhibition of aquaporin-3 in macrophages by a monoclonal ... - Nature
2020年11月9日 · Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H 2 O 2) that is expressed in various epithelial cells and in macrophages. Here, we developed an anti-AQP3...
Aquaporin-3 in Cancer - PMC
Increasing evidence suggests that the water/glycerol channel aquaporin-3 (AQP3) plays a pivotal role in cancer metastasis. AQP3 knockout mice were resistant to skin tumor formation and overexpression correlated with metastasis and poor prognosis …
AQP3 aquaporin 3 (Gill blood group) [ (human)] - National Center …
2024年10月28日 · This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of …
Aquaporins: Important players in the cardiovascular …
2022年9月1日 · AQP3 and AQP10 exert a similar action in cardiovascular energy metabolism to AQP7, and they control the glycerol influx/efflux in metabolic organs, manifesting a close correlation with metabolic diseases such as cardiac hypertrophy [114].
AQP3 aquaporin 3 (Gill blood group) [ Homo sapiens (human) ]
2024年6月17日 · Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree.
Roles of Aquaporin-3 in the Epidermis - ScienceDirect
2008年9月1日 · Aquaporin-3 (AQP3) is a membrane transporter of water and glycerol expressed in plasma membranes in the basal layer keratinocytes of epidermis in normal skin. AQP3 expression in human skin is increased in response to skin stress in diseases such as atopic eczema, to various agents such as retinoic acid, and in skin carcinomas.
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