Robust axis elongation by Nodal-dependent restriction of BMP …
2024年2月19日 · When analyzing the effect of BMP overactivation on axis elongation in embryos by overexpressing caAlk8, we found that the AP length of the mesendoderm was reduced at bud stage (Fig. S10A,B), consistent with previous findings (Myers et al., 2002a).
Mechanics of anteroposterior axis formation in vertebrates
The vertebrate anteroposterior (AP) axis forms through elongation of multiple tissues during embryonic development. Tight coordination among tissues that originate from different germ layers is required for proper elongation.
Local mechanical forces promote polarized junctional assembly and axis ...
2016年1月9日 · Axis elongation is a conserved morphogenetic process is which the basic body plan of an animal is established. In vertebrates, axis elongation involves convergence and extension movements mediated by cell intercalation, cell migration, and oriented cell division (Bénazéraf and Pourquié, 2013).
Controlling organoid symmetry breaking uncovers an excitable …
2023年1月18日 · We propose that secreted inhibitors of the WNT pathway in the form of SFRPs are required for stable elongation along a single A-P axis (Figure 4L). Our model of the elongating neural tube as an excitable system could generalize to other organ primordia in which asymmetric signals are coupled to morphogenesis, especially those in which WNT and ...
An actin-based viscoplastic lock ensures progressive body-axis elongation
2019年8月28日 · Body-axis elongation constitutes a key step in animal development, laying out the final form of the entire animal.
A fluid-to-solid jamming transition underlies vertebrate body axis ...
2018年9月5日 · Here, by combining direct in vivo measurements of tissue mechanics with analysis of cellular dynamics, we show that during vertebrate body axis elongation, posterior tissues undergo a jamming...
Regulation of axial elongation by Cdx - ScienceDirect
2022年3月1日 · The primordia of the post-otic mouse embryo forms largely from a bipotential cell population containing neuromesodermal progenitors (NMP) which reside in the tail bud and contribute to the elaboration of the major body axis after gastrulation.
Robust axis elongation by Nodal-dependent restriction of BMP
2024年2月15日 · Translating these ex vivo observations to the intact embryo showed that, similar to explants, Nodal signaling suppresses the effect of BMP signaling on cell intercalations in the dorsal domain, thus allowing robust embryonic axis elongation.
Dynamics and mechanisms of posterior axis elongation in the
2018年10月3日 · During posterior axis elongation, the spatial organization of embryonic tissues is stereotypical among vertebrate embryos and can be schematized as a general framework (Fig. 1). The neural tube and the notochord are located axially.
Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis ...
2010年9月14日 · This structural transformation is characterized by a striking directionality in which cell movements are oriented perpendicular to the direction of tissue elongation, a process known as cell intercalation. Cell intercalation is essential for axis elongation in frogs, fish, chicks, flies, and ascidians (Keller et al., 2000, Solnica-Krezel, 2005).