Azacitidine - Wikipedia
网页Azacitidine is a chemical analogue of the nucleoside cytidine, which is present in DNA and RNA. It is thought to have antineoplastic activity via two mechanisms – at low doses, by inhibiting of DNA methyltransferase, causing hypomethylation of DNA, [16] and at high doses, by its direct cytotoxicity to abnormal hematopoietic cells in the bone ...
阿扎胞苷 - 维基百科，自由的百科全书
网页阿扎胞苷 （INN：Azacitidine），有时也称为 5-阿扎胞苷 （5-Azacitidine），商品名维达莎或委丹扎（Vidaza），是一种 胞苷 （组成 DNA 与 RNA 的 核苷 之一） 类似物，由 捷克斯洛伐克 学者 弗朗蒂斯克·索姆 （英语：František Šorm） （František Šorm）于20世纪60年代首 …
5-Azacytidine：一种具有多重功能的抗肿瘤药物
网页5-Azacytidine是一种具有多重功能的抗肿瘤药物，具有特异型抑制 DNA 甲基化的作用，可以逆转表观遗传变化并诱导细胞自噬 (autophagy)。 虽然其不良反应需要关注，但在正确的使用下，它可以为肿瘤患者提供一种有效的治疗选择。
Azacitidine Uses, Side Effects & Warnings - Drugs.com
网页2023年10月9日 · Generic name: azacitidine (oral/injection) [ ay-za-SYE-ti-deen ] Brand names: Onureg, Vidaza. Dosage forms: injectable powder for injection (100 mg), oral tablet (200 mg; 300 mg) Drug class: Miscellaneous antineoplastics. Medically reviewed by Drugs.com on Oct 9, 2023. Written by Cerner Multum.
Azacitidine: Uses, Interactions, Mechanism of Action - DrugBank …
网页Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside present in DNA and RNA. 1,2 It induces antineoplastic activity by inhibiting DNA methyltransferase at low doses and inducing cytotoxicity by incorporating itself …
Azacitidine: MedlinePlus Drug Information
网页Azacitidine is used to treat acute myeloid leukemia (AML; cancer of the white blood cells) in adults who improved after chemotherapy, but who are unable to complete intensive curative therapy. Azacitidine is in a class of medications called demethylation agents.
5-氮杂胞嘧啶核苷 - 百度百科
网页5-氮杂胞嘧啶核苷，又名5-氮胞苷、 阿扎胞苷 ，是一种有机化合物，化学式为C8H12N4O5，主要用作抗肿瘤药，临床上用于治疗乳腺癌、肠癌、黑色素瘤、急性粒细胞性白血病等。 2017年10月27日，世界卫生组织国际癌症研究机构公布的致癌物清单初步整理参考， 阿扎胞苷在2A类致癌物清单中。 [2] 中文名. 5-氮杂胞嘧啶核苷. 外文名. 5-azacytidine. 化学式. C8H12N4O5. 分子量. 244.205. CAS登录号. 320-67-2. EINECS登录号. 206-280 …
Azacitidine - NCI - National Cancer Institute
网页This page contains brief information about azacitidine and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
Azacitidine - Pharmaceutical Drugs - NCBI Bookshelf
网页After incorporation into DNA, azacitidine inhibits DNA methyl transferase noncompetitively, blocking cytosine methylation in newly replicated DNA. Since hypomethylation patterns in DNA are related to gene expression, this may be the mechanism by which azacytidine induces a range of biological effects (Glover et al., 1987).
Azacitidine - Nature Reviews Drug Discovery
网页Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases 4 (Fig. 1). It was originally developed as a cytotoxic agent, and an...
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