The CCR5-Delta32 Genetic Polymorphism and HIV-1 Infection ...
网页2018年10月16日 · In CCR5-delta32 heterozygotes genetic model, we have detected a statistically significant increased susceptibility to HIV-1 infection (OR=1.16, 95%CI=1.02-1.32, P=0.024) for healthy control. Meanwhile, we have found significantly reduced the risk of HIV-1 infection in the delta32 homozygous genetic model (OR=0.25, 95%CI=0.09-0.68, …
CCR5 - Wikipedia
网页C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. [ 5 ] In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3.
德尔塔32突变基因 - 百度百科
网页CCR5 32是指CCR5基因的32个碱基缺失的突变，即在CCR5等位基因编码区域第185位氨基酸密码子以后发生了32个碱基缺失，导致读码框架错位，缺失了与G蛋白信号通路相关的胞外第三环结构，从而使CCR5蛋白无法正常穿膜表达于细胞膜上，进而使HIV-1 gp120不能与CCR5 32有效 ...
CCR5-Δ32 biology, gene editing, and warnings for the future of …
网页2020年3月30日 · The elements important in HIV binding and structure (PA12 binding site and 2D7 binding site, and sites of tyrosine sulfonation and G-protein linkage) are highlighted. The CCR5-Δ32 deletion site is denoted with a triangle and …
Could the CCR5-Delta32 mutation be protective in SARS-CoV-2
网页2021年12月16日 · These results suggest that CCR5-delta32 may be protective against SARS-CoV-2 infection, as it is against HIV infection, and could be predictive of COVID-19 risk and severity. Further studies based on samples from populations of different genetic backgrounds are needed to validate these statistically obtained findings.
Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell ...
网页2009年2月12日 · Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with...
CCR5Δ32 mutation and HIV infection: basis for curative HIV …
网页The C-C chemokine receptor 5 (CCR5) is expressed on potential human immunodeficiency virus (HIV) target cells and serves as the predominant co-receptor for viral entry during initial transmission and through the early stages of infection. A homozygous Δ32 mutation in the CCR5 gene prevents CCR5 cell ….
HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell ...
网页2019年3月5日 · An adult infected with HIV-1 who underwent allogeneic haematopoietic stem-cell transplantation for Hodgkin’s lymphoma using cells from a CCR5Δ32/Δ32 donor achieved full remission of HIV-1 for ...
Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32 ...
网页2014年8月28日 · Homozygosity for a 32-bp deletion in the CCR5 allele (CCR5 delta32) prevents cellular entry of CCR5-tropic (R5-tropic) HIV type 1 (HIV-1) strains.
Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 …
网页2021年12月30日 · These results suggest that CCR5-Δ32 may be protective against SARS-CoV-2 infection, as it is against HIV infection, and could be predictive of COVID-19 risk and severity. Further studies based on samples from populations of different genetic backgrounds are needed to validate these statistically obtained findings.