COX-2 Inhibitors: What They Are, Uses & Side Effects - Cleveland Clinic
2022年5月24日 · They treat the pain and inflammation of many types of arthritis and other types of short-term pain. COX-2 inhibitors are as effective as traditional NSAIDs but cause less stomach and intestinal problems. Celecoxib (Celebrex®) is the only COX-2 inhibitor available in the U.S.
List of COX-2 Inhibitors Uses, Types & Side Effects - Drugs.com
2023年4月12日 · COX-2 inhibitors may be used to treat mild-to-moderate pain or inflammation caused by a wide range of conditions such as: Ankylosing spondylitis. Hereditary polyps of the colon. Juvenile rheumatoid arthritis in children aged from two years. Menstruation. Osteoarthritis.
Cyclooxygenase (COX) Enzymes, Inhibitors, and More - Verywell …
2024年5月27日 · Cyclooxygenase (COX) is an enzyme that forms prostaglandins, prostacyclins, and thromboxanes —substances called "prostanoids" that are responsible for the inflammatory response. If you have ever experienced inflammation -related pain—for example, due to arthritis —you've felt cyclooxygenase at work.
Cyclooxygenase-2 (COX-2) in inflammatory and ... - PubMed
COX-2 is the inducible isoform, rapidly expressed in several cell types in response to growth factors, cytokines, and pro-inflammatory molecules. Since its discovery in the early 1990s, COX-2 has emerged as a major player in inflammatory reactions in peripheral tissues.
Overview of COX-2 selective NSAIDs - UpToDate
2024年5月23日 · An overview of the COX-2 selective NSAIDs, particularly of those characteristics that distinguish them from COX nonselective NSAIDs, is presented here. The uses of COX-2 selective NSAIDs in specific disorders are also discussed …
Cyclooxygenase 2 - an overview | ScienceDirect Topics
Cyclooxygenase-2 (COX-2) is an enzyme that plays a significant role in tissue inflammation by converting arachidonic acid into prostaglandins, particularly prostaglandin E2 (PGE2).
COX Inhibitors - StatPearls - NCBI Bookshelf
2024年2月28日 · The COX enzyme catalyzes the conversion of arachidonic acid into prostaglandin. [5] The enzyme has 2 known isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). There are over 20 COX inhibitors, varying in the amount they inhibit each isoform. COX-2-specific NSAIDs work by preferentially inhibiting COX-2.
COX-2's new role in inflammation - Nature Chemical Biology
2010年5月2日 · COX-2 is the enzyme largely responsible for causing inflammation, a common mechanism of disease. A study now reports that derivatives generated by COX-2 from naturally occurring ω-3 fatty...
What Are COX-2 Inhibitors? - Everyday Health
2016年11月3日 · Also known as selective COX-2 inhibitors, these medications treat inflammatory pain. Selective COX-2 inhibitors are a type of nonsteroidal anti-inflammatory medication (also known as...
What Are Cox-2 Inhibitors? Side Effects, List, Uses & Dosage - MedicineNet
Cox-2 Inhibitors (Cox-2 inhibitor drugs) are prescription drugs used to treat the pain of arthritis conditions, menstrual cramps, and acute injuries such as sports injuries. Common side effects of COX-2 inhibitors are sinusitis, headache, flatulence, and insomnia.
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