CXCR4 - Wikipedia
CXCR4 is one of several chemokine co-receptors that HIV can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these …
CXCR4 Gene - GeneCards | CXCR4 Protein | CXCR4 Antibody
2024年10月1日 · CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome 1 and Macroglobulinemia, …
Structural insights into CXCR4 modulation and oligomerization
2024年9月23日 · We show that CXCR4 adopts distinct subunit conformations in trimeric and tetrameric assemblies, highlighting how oligomerization could allosterically regulate chemokine …
Frontiers | The Chemokine Receptor CXCR4 in Cell Proliferation …
2020年8月27日 · The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the …
CXCR4 C-X-C motif chemokine receptor 4 [ (human)] - National …
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 …
CXCR4 gene - MedlinePlus
The CXCR4 gene provides instructions for making a receptor protein that spans the outer membrane of cells, specifically white blood cells and cells in the brain and spinal cord (central …
CXCR4, the master regulator of neutrophil trafficking in
In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone …
The Intricate Role of CXCR4 in Cancer - PMC - PubMed Central …
CXCR4, initially discovered for its involvement in HIV entry and leukocytes trafficking, is overexpressed in more than 23 human cancers. Cancer cell CXCR4 overexpression …
At the Bench: Pre-clinical evidence for multiple functions of CXCR4 …
CXCR4 signaling promotes tumor growth in primary tumors from sites including prostate, breast, and brain. Various isoforms of CXCL12 produced by carcinoma-associated fibroblasts in a …
Involvement of CXCR4 in Normal and Abnormal Development
CXC motif chemokine receptor type 4 (CXCR4) is associated with normal and abnormal development, including oncogenesis. The ligand of CXCR4 is stromal cell-derived factor …