Calmodulin - Wikipedia
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. [1] It is an intracellular target of the secondary messenger Ca 2+, and the binding of Ca 2+ is required for the activation of calmodulin.
Calmodulin - Definition, Function and Structure - Biology Dictionary
2017年7月4日 · Calmodulin, or calcium-modulated protein, is a calcium-binding protein found in the cytoplasm of all eukaryotic cells. It interacts with many other proteins in the cell, and acts as a regulator or an effector molecule in a wide variety of cellular functions.
Calmodulin - an overview | ScienceDirect Topics
Calmodulin, the ubiquitous and multifunctional Ca 2+ binding protein, mediates many of the regulatory effects of Ca 2+, including the contractile state of smooth muscle. Calmodulin was discovered as an activator of cyclic nucleotide phosphodiesterase (PDE) (Cheung, 1970; Kakiuchi et …
Calmodulin Mutations in Human Disease - PMC - PubMed …
Calmodulin (CaM) is a small but vital protein that is able to rapidly transmit information about changes in Ca 2+ concentrations to its regulatory targets. CaM plays a critical role in cellular Ca 2+ signaling, and interacts with a myriad of target proteins.
Calmodulin 1 - Wikipedia
Calmodulin 1 is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding EF hand motifs.
Molecule of the Month: Calmodulin - RCSB: PDB-101
Calmodulin changes shape when it binds to calcium and can activate over 300 essential proteins. Each of its four high-affinity calcium binding sites, called EF-hands, contains a characteristic loop flanked by two alpha helices.
The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and ...
Calmodulin (CaM) is the principal Ca 2+ sensor protein in all eukaryotic cells, that upon binding to target proteins transduces signals encoded by global or subcellular-specific changes of Ca 2+ concentration within the cell.
Calmodulin: an introduction - PubMed
Calmodulin is the most widely distributed and most versatile member of a family of calcium-binding proteins which probably serve as receptors for the Ca2+ signal. Through the regulation of a wide variety of intracellular enzymes, calmodulin plays a key role in …
Calcium Signalling in Heart and Vessels: Role of Calmodulin and ...
Calmodulin (CaM) is involved in the regulation and transduction of calcium signalling. CaM is an important primary sensor of intracellular calcium levels in eukaryotic cells, playing a pivotal role in the transduction and deciphering of calcium signalling [38, 39].
Calmodulin: The switch button of calcium signaling - PubMed
2021年8月23日 · Calmodulin (CaM), a calcium sensor, decodes the critical calcium-dependent signals and converts them into the driving force to control various important cellular functions, such as ion transport.