More from Cancer Cell - Cell Press
Latest cancer news and research. ISSN: 1878-3686 (online); 1535-6108 (print) Cancer Cell provides a high-profile forum to promote major translational and clinical advances in cancer research and oncology.
Issue: Cancer Cell
2024年11月11日 · Combinatorial immunotherapy may improve the efficacy of neoadjuvant checkpoint inhibitors in locoregionally advanced melanoma. In this issue of Cancer Cell, Davar and colleagues report a promising phase 2 neoadjuvant trial of the TLR9 agonist vidutolimod in combination with nivolumab.
New articles: Cancer Cell
2024年11月7日 · Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy. Yang et al. identify CD49f as a prominent tumor-initiating cells (TIC) marker in HCC and reveal a reciprocal loop between CD49f-high TICs and neutrophils that promotes tumor immune evasion by enhancing CD155 expression.
Mammalian SWI/SNF chromatin remodeling complexes promote …
2023年8月3日 · In this study, de Miguel et al. find that mammalian SWI/SNF chromatin-remodeling complexes promote osimertinib resistance in EGFR-mutant lung cancer model systems via changes in chromatin accessibility, which underlie resistance-associated gene expression and cancer cell proliferation.
Interactions between cancer cells and immune cells drive ... - Cell …
2021年6月3日 · To explore potential mechanisms underlying macrophage induction of the MES-like state in cancer cells, we examined putative ligand-receptor interactions predicted by the glioblastoma scRNA-seq datasets (Neftel et al., 2019).
Redefining breast cancer subtypes to guide treatment ... - Cell Press
Breast cancer treatment now includes platinum-based agents, poly (ADP-ribose) polymerase (PARP) inhibitors, phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) inhibitors, mammalian target of rapamycin (mTOR) inhibitors, dual HER2-targeting regimens, and immunotherapy for specific HR/HER2-defined subtypes (Bergin and Loi, 2019 ...
Integrated Omics of Metastatic Colorectal Cancer - Cell Press
Here, we present a global integration of genomics, proteomics, and phosphoproteomics in metastatic CRC from a Chinese cohort. Integrated analyses of multi-omic data demonstrated distinct proteomic and phosphoproteomic characteristics for subtypes and metastasis.
Conserved pan-cancer microenvironment subtypes predict ... - Cell …
In the MF Portrait, potentially targetable genomic alterations in the cancer cells related to different processes such as cell proliferation, oncogenic signaling, EMT, angiogenesis, and anti-tumor immunity are listed and prioritized.
Proteogenomic data and resources for pan-cancer analysis - Cell …
2023年8月14日 · Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms
Comprehensive peripheral blood immunoprofiling reveals ... - Cell …
2024年5月13日 · Growing evidence suggests that analysis of peripheral blood leukocytes can inform immunotherapy selection in patients with solid tumors. 13 Findings from a pan-cancer study have shown that high levels of naive B cells in peripheral blood associate with improved survival after ICB treatment. 14 High levels of dendritic cells correlate with ...