CD16a生物学以及提高ADCC作用的策略 - 知乎 - 知乎专栏
改善nk细胞adcc的一种策略是通过靶向adam17来防止cd16a脱落。 研究发现，对NK细胞中使用CRISPR/Cas9技术敲除ADAM17，显示出更好的IFN-γ生成和体内外ADCC活性。
CD16 is indispensable for antibody-dependent cellular ... - Nature
2016年9月27日 · CD16, the FcγRIIIA, is essential for ADCC by NK cells, and is also expressed by a subset of human blood monocytes. We found that human CD16− expressing monocytes have a broad spectrum of...
靶向CD16A，激活先天免疫系统的ADCC效应 - 知乎 - 知乎专栏
靶向CD16A，激活先天免疫系统的ADCC效应. NK细胞作为先天性免疫细胞中的杀伤细胞，可直接杀伤病原体和肿瘤细胞。. 与T细胞相比， NK细胞具有更强的肿瘤识别和杀伤能力，以及更强的现货型应用的潜质。. 如何改造治疗性抗体药物的恒定区（Fc端）使其更好地 ...
Comparison of the different anti-CD16 antibody clones in the
2023年6月11日 · CD16 (Fcγ receptor III) is a receptor expressed on NK cells that facilitates antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. The enhancement...
NK cell CD16 surface expression and function is regulated by a ...
CD16-mediated activation of NK cells is a potent signal for inducing ADCC when using these antibodies. NK cells can eliminate CD20-expressing Burkitt’s lymphoma cells pre-coated with the monoclonal antibody rituximab through CD16 binding to the Fc portion of the antibody.
From CD16a Biology to Antibody-Dependent Cell-Mediated …
Upon recognition of IgG-opsonized targets through CD16a, NK cells trigger a potent cytotoxic mechanism called antibody-dependent cell-mediated cytotoxicity (ADCC), leading to the death of the target cell.
A novel endogenous CD16-Expressing Natural Killer Cell for …
2021年7月1日 · Fcγ receptor IIIA, also known as CD16, further confers NK cells with antibody-dependent cell-mediated cytotoxicity (ADCC), one mechanism of action of antibody-based immunotherapy. Here, we establish a novel human NK cell line, oNK-1, endogenously expressing CD16 along with high levels of NK activation markers and low levels of NK inhibitory ...
CD16 is indispensable for antibody-dependent cellular
2016年9月27日 · CD16, the FcγRIIIA, is essential for ADCC by NK cells, and is also expressed by a subset of human blood monocytes. We found that human CD16- expressing monocytes have a broad spectrum of ADCC capacities and can kill cancer cell lines, primary leukemic cells and hepatitis B virus-infected cells in the presence of specific antibodies.
Antibody-dependent cell cytotoxicity: immunotherapy strategies ...
Antibody-dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of cell-to-cell cytolysis executed by immune cells expressing FcRIIIA (CD16A). These effectors include not …
Evaluating Human Natural Killer Cells Antibody-dependent Cellular ...
2022年1月5日 · Most importantly, CD16 is a low affinity Fc receptor for IgG that mediates the antibody-dependent cellular cytotoxicity (ADCC) of NK cells, bridging the innate and adaptive immunities.