CD8A - Wikipedia
The CD8 protein is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting cell (APC) in the context of class I MHC molecules.
CD8A Gene - GeneCards | CD8A Protein | CD8A Antibody
2024年10月1日 · CD8A (CD8 Subunit Alpha) is a Protein Coding gene. Diseases associated with CD8A include Immunodeficiency 116 and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are TCR Signaling (Qiagen) and Network map …
CD8 - Wikipedia
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell - antigen interactions.
CD8A - an overview | ScienceDirect Topics
A CD45-based segmentation strategy was employed to define an immune compartment for ROIs from the melanoma samples, and enrichment of immune protein targets, such as activated cytolytic T-cell markers (CD8A and CD45RO) and B-cell markers (CD19/CD20), was observed in patients with pCR.
CD8A CD8 subunit alpha [ Homo sapiens (human) ] - National …
2024年9月17日 · Summary. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.
UniProt
CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers.
CD8A is a Promising Biomarker Associated with Immunocytes …
2023年4月17日 · CD8A can be a novel candidate biomarker for BPD, which plays an essential role in the onset and progress of hyperoxia-related BPD via the disruption of immune cell functions. Keywords: bronchopulmonary dysplasia, CD8A, preterm infants, immunocytes infiltrate, hyperoxia. Go to: Introduction.
A new way to maintain CD8 - Nature
2022年7月12日 · The CD8 serves as a coreceptor with the T-cell receptor (TCR) on T cells for their activation and clonal expansion to recognize antigens presented by MHC class-I molecules on antigen-presenting...
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...
CD8αα and CD8αβ: truly different?: Trends in Immunology - Cell …
2002年4月1日 · These two papers provide compelling evidence that the CD8αα homodimer and CD8αβ heterodimer are truly different in their functions, at least in mice. It is noteworthy that a TL homologue has not been found in humans, and so the question remains as to whether these findings apply to human CD8.