Circular RNA - Wikipedia
网页In molecular biology, circular RNA (or circRNA) is a type of single-stranded RNA which, unlike linear RNA, forms a covalently closed continuous loop. In circular RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together.
The biogenesis, biology and characterization of circular RNAs
网页2019年8月8日 · Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific...
Circular RNAs: Characterization, cellular roles, and applications
网页2022年5月17日 · Liu and Chen review the growing toolbox to characterize circular RNA, the resulting emerging understanding of their biological roles, and how circular RNA are being utilized for biomedical applications.
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA …
网页Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′ or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA degradation by exonucleases, thereby empowering them with high pharmaceutical stability and biostability relative to current standard-of-care linear mRNA.
Specific expression and functions of circular RNAs
网页2022年2月15日 · In recent years, circular RNAs (circRNAs), a new class of RNA molecules characterized by their covalently closed circular structure, have become a new research paradigm in RNA biology.
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA …
网页2022年6月2日 · Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5' or 3' ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA degradation by exonucleases, thereby empowering them with high pharmaceutical stability and biostability relative to cur ….
Advances in Circular RNA and Its Applications - PMC
网页2022年5月27日 · Circular RNA (circRNA) is a novel endogenous non-coding RNA (ncRNA) that, like microRNA (miRNA), is a rapidly emerging RNA research topic. CircRNA, unlike traditional linear RNAs (which have 5' and 3' ends), has a closed-loop structure that is unaffected by RNA exonucleases.
Circular RNAs: diversity of form and function - PMC
网页Circular RNAs have unique properties including the potential for rolling circle amplification of RNA, the ability to rearrange the order of genomic information, protection from exonucleases, and constraints on RNA folding.
The expanding regulatory mechanisms and cellular functions of circular …
网页2020年5月4日 · Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs) through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure and turnover and...
Circular RNA: metabolism, functions and interactions with …
网页2020年12月14日 · Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs.