Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer …
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and impaired cognitive functions. Fascaplysin is a β-carboline alkaloid isolated from marine sponge Fascaplysinopsis bergquist in 1988. Previous studies have shown that fascaplysin might act on acetylcholinesterase and β-amyloid (Aβ) to produce anti-AD properties.
Marine-Derived Lead Fascaplysin: Pharmacological Activity, Total …
2023年3月31日 · Fascaplysin exhibited promising P-gp activation together with AChE inhibition at 1 mM, with good medication safety (LS-180: IC 50 > 10 μM, hGF: 4 μM), clearly indicating their promise for the development as an anti-Alzheimer agent .
Marine-Derived Lead Fascaplysin: Pharmacological Activity, Total ...
2023年3月31日 · Fascaplysin exhibited promising P-gp activation together with AChE inhibition at 1 mM, with good medication safety (LS-180: IC 50 > 10 μM, hGF: 4 μM), clearly indicating their promise for the development as an anti-Alzheimer agent .
9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor …
2019年2月18日 · β-Amyloid (Aβ) is regarded as an important pathogenic target for Alzheimer’s disease (AD), the most prevalent neurodegenerative disease. Aβ can assemble into oligomers and fibrils, and produce neurotoxicity.
9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor ... - PubMed
2019年2月18日 · β-Amyloid (Aβ) is regarded as an important pathogenic target for Alzheimer's disease (AD), the most prevalent neurodegenerative disease. Aβ can assemble into oligomers and fibrils, and produce neurotoxicity. Therefore, Aβ aggregation inhibitors may have anti-AD therapeutic efficacies.
Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer ...
2019年11月5日 · Previous studies have shown that fascaplysin might act on acetylcholinesterase and β-amyloid (Aβ) to produce anti-AD properties. In this study, a series of fascaplysin derivatives were synthesized. The cholinesterase inhibition activities, the neuronal protective effects, and the toxicities of these compounds were evaluated in vitro .
Fascaplysin Derivatives Are Potent Multi-target Agents Against ...
2019年10月22日 · Results suggested that fascaplysin derivatives are potent multi-target agents against AD, and might be clinical useful for AD treatment. Alzheimer's disease (AD) is characterized by the progressive neurodegeneration and the impaired cognitive functions.
Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer ...
Fascaplysin is a β-carboline alkaloid isolated from marine sponge Fascaplysinopsis Bergquist sp. in 1988. Previous studies have shown that fascaplysin might act on acetylcholinesterase and...
Identification of Novel Candidate Targets for Fascaplysin through
2024年9月4日 · Additionally, its ability to inhibit acetylcholinesterase suggests potential for Alzheimer’s disease treatment (Bharate et al., 2012). As a multitarget drug, fascaplysin can act on several biological targets simultaneously, offering advantages for treating complex diseases by potentially improving bioavailability and pharmacokinetic profiles ...
Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer …
2019年11月20日 · Alzheimer's disease (AD) is characterized by progressive neurodegeneration and impaired cognitive functions. Fascaplysin is a β-carboline alkaloid isolated from marine sponge Fascaplysinopsis bergquist in 1988. Previous studies have shown that fascaplysin might act on acetylcholinesterase and …