FCGR3B Gene - GeneCards | FCG3B Protein | FCG3B Antibody
2024年10月2日 · FCGR3B (Fc Gamma Receptor IIIb) is a Protein Coding gene. Diseases associated with FCGR3B include Neutropenia, Severe Congenital, X-Linked and Neonatal Alloimmune Neutropenia . Among its related pathways are Innate Immune System and Metabolism of proteins .
Expression, Role, and Regulation of Neutrophil Fcγ Receptors
2019年8月27日 · Indeed, FcγRs (via IgG antibodies) confer neutrophils with a key feature of the adaptive immunity: an antigen-specific cell response. This review summarizes the expression and function of FcγRs on human neutrophils in health and disease and how they are affected by polymorphisms in the FCGR loci.
Human and mouse neutrophils share core transcriptional ... - Nature
2023年12月8日 · Orthologs with higher expression in human neutrophils included FCGR3A and FCGR3B (encoding CD16A and CD16B, respectively), which both are one-to-many orthologs of mouse Fcgr4.
Single-cell transcriptome identifies FCGR3B upregulated subtype …
The expression level per cluster for CCL3L1 and FCGR3B marker in severe, moderate and control single-cell transcriptome data clearly reveals a distinct pattern of FCGR3B and restrictive expression for MoAM (cluster 11) in severe COVID-19 cases (Figure S7; Tables S10–S12).
FCGR3B - Wikipedia
FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (C luster of D ifferentiation 16b), is a human gene. [5] Clinical relevance. Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis. [6] See also. CD16. Cluster of differentiation. References.
Fcγ receptors and immunomodulatory antibodies in cancer
2023年12月7日 · Neutrophils isolated from healthy donors with low copy numbers of FCGR3B (CNR1 deletion) showed higher levels of ADCC in the presence of trastuzumab or cetuximab and tumour cells expressing the...
FCGR3B Fc gamma receptor IIIb [ (human)] - National Center for ...
2024年4月11日 · Low copy number of the Fc-gamma receptor 3B gene FCGR3B is a risk factor for primary Sjogren's syndrome. Studies indicate beta-defensins (DEFB4, DEFB103, DEFB104), chemokine ligand 3 like 1 (CCL3L1), Fc gamma receptor 3B (FCGR3B), and complement component C4 (C4) for copy number variation in disease association.
Fcγ receptors: structure, function and role as genetic risk …
2009年5月7日 · FCGR3B. Three different allotypic variants of FcγRIIIb, NA1, NA2 and SH, have been identified through serological studies. The sequence bases for these FCGR3B variants are now known . The six SNP...
FCGR3B Fc gamma receptor IIIb [ Homo sapiens (human) ]
2024年9月12日 · The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation.
FcγRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells …
2019年1月29日 · The function of the low-affinity IgG-receptor FcγRIIIb (CD16b), which is uniquely and abundantly expressed on human granulocytes, is not clear. Unlike the other Fcγ receptors (FcγR), it is a glycophosphatidyl inositol (GPI) -anchored molecule and does not have intracellular signaling motifs.