Fumaric acid esters in the management of psoriasis - PMC
网页2015年1月5日 · Fumaric acid esters (FAE) are small molecules with immunomodulating, anti-inflammatory, and anti-oxidative effects. FAE were introduced as a systemic psoriasis treatment in 1959 and empirically developed further between 1970 and 1990 in Germany, Switzerland, and the Netherlands. The development of FAE as psoriasis treatment did …
Psoriasis clinical guideline - American Academy of Dermatology
网页Fumaric acid esters are approved in the United States for treatment of relapsing forms of multiple sclerosis and can be considered for psoriasis. Related Academy resources Clinical guideline flowchart for treating psoriasis patients using systemic non-biologics (PDF)
Oral fumaric acid esters for psoriasis: abridged Cochrane …
网页2016年8月29日 · Fumaric acid esters (FAE s) are licensed for the treatment of moderate‐to‐severe psoriasis in Germany but are also used off‐label in many other countries. We conducted this systematic review to synthesize the highest‐quality evidence for the benefits and risks of FAE s for psoriasis.
Fumaric Acid and its Esters: An Emerging Treatment for Multiple ...
网页At present, fumaric acid esters (FAE) are licensed for the treatment of psoriasis. Several lines of evidence have demonstrated immunomodulatory effects for FAE. Clinical studies in psoriasis showed a reduction of peripheral CD4 + - and CD8 + -T-lymphocytes due to the ability of FAE to induce apoptosis.
Fumaric acid esters in the management of psoriasis
网页2015年1月5日 · FAE were introduced as a systemic psoriasis treatment in 1959 and empirically developed further between 1970 and 1990 in Germany, Switzerland, and the Netherlands. The development of FAE as psoriasis treatment did not follow the traditional drug development phases.
Efficacy, effectiveness and safety of fumaric acid esters in the ...
网页2016年8月1日 · Fumaric acid esters (FAEs) are increasingly used as a systemic treatment for psoriasis, but there are still uncertainties regarding their suitability. The objective of this systematic review was to assess the evidence for the efficacy and safety of FAEs in psoriasis treatment.
Fumaric acid esters for psoriasis: a systematic review
网页2016年6月7日 · Overall, the use of fumaric acid esters for the treatment of moderate to severe psoriasis has been shown to be an effective and safe long term treatment agent. Gastrointestinal side effects and flushing are common …
Fumaric acid esters in the management of psoriasis
网页2014年9月1日 · About 50%–70% of patients achieve at least 75% improvement in psoriasis severity after 16 weeks of treatment. Common adverse events of FAE include gastrointestinal complaints and flushing symptoms, which lead to treatment discontinuation in up to 40% of patients.
Fumaric acid esters in the management of psoriasis - PubMed
网页2015年1月5日 · Fumaric acid esters (FAE) are small molecules with immunomodulating, anti-inflammatory, and anti-oxidative effects. FAE were introduced as a systemic psoriasis treatment in 1959 and empirically developed further between 1970 and 1990 in Germany, Switzerland, and the Netherlands.
Fumaric acid esters for psoriasis: a systematic review
网页The findings suggest that FAEs are a safe and effective treatment option for the management of moderate to severe psoriasis in adult patients. Gastrointestinal side effects may occur on treatment initiation and may be minimised by slow dose titration.