Progranulin - ALZFORUM
Synonyms: GRN, PGRN, granulin precursor, granulin, proepithelin, PC cell-derived growth factor (PCDGF), GP88, PEPI, CLN11, Granulin Epithelin Precursor (GEP)
Granulins: The Missing Link between Progranulin and Lysosome
2017年8月21日 · Next, his group is working to test the role of individual granulins, to determine which if any might restore lysosome function in various models of granulin deficiency, and how …
Progranulin-Boosting Drug Moves into Phase 2 for ... - ALZFORUM
The Phase 2 clinical trial, which will be double-blind, randomized, and placebo-controlled, is set to begin in 2014, Patzke said. Thirty granulin mutation carriers in the symptomatic or prodromal …
Could Extra Granulins Be the Problem in Progranulin ... - ALZFORUM
2015年7月6日 · Next, the authors examined granulins in tissues from people who died of FTD with TDP-43 proteinopathy. They generated an antibody specific to one human granulin, …
Sorting Progranulin With Sortilin—New Clues to FTLD Pathology
26 Nov 2010. Progranulin, a raw form of granulin (GRN), landed center stage of neurodegeneration research four years ago (see ARF related news story), when scientists …
DNL593 - ALZFORUM
2023年10月23日 · DNL593 is a replacement therapy for frontotemporal dementia caused by granulin gene mutations. In this type of FTD, a deficit of brain progranulin protein interferes …
Does Progranulin Play Both Sides in AD and FTD? - ALZFORUM
2013年4月26日 · Papers. Ward ME, Miller BL.Potential mechanisms of progranulin-deficient FTLD. J Mol Neurosci. 2011 Nov;45(3):574-82.
AL001 Boosts Progranulin. Does it Slow Frontotemporal Dementia?
20 Aug 2021. Autosomal-dominant mutations underlie about 40 percent of frontotemporal dementia cases. This strong genetic component comes with a silver lining—it gives scientists …
Granulin loss of function in human mature brain organoids …
2023年3月4日 · Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology. Stem Cell Reports. 2023 Mar 14;18(3):706-719. Epub 2023 Feb 23 …
FTD Risk Factor Confirmed, Alters Progranulin Pathways
2012年8月24日 · Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Arch Neurol . 2011 May;68(5):581-6. …