Human leukocyte antigen - Wikipedia
The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [ 1 ] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [ 2 ]
Human Leukocyte Antigen (HLA) System - The Merck Manuals
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. It encodes cell surface molecules specialized to present antigenic peptides to the T-cell receptor (TCR) on T cells.
HLA-A - Wikipedia
HLA-A is one particular group of the human Class I MHCs. It consists of several hundred different genes and several thousand variant alleles. HLA-A is critical to the cytotoxic t-cell controlled immune response to viruses and other intracellular pathogens.
HLAMatchmaker
HLAMatchmaker is a structurally based algorithm that considers HLA alleles as strings of distinct molecular configurations that can be recognized by HLA antibodies important in transplantation.
HLA-ABC Monoclonal Antibody (W6/32), PE, eBioscience™
Description: The W6/32 monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, C. MHC class I antigens associated with beta 2-microglobulin are expressed by all human nucleated cells and are central in cell-mediated immune response and tumor surveillance.
HLA Typing: Purpose, Genetics, Procedure, Interpretation
2023年10月9日 · HLA proteins, known as markers, help the immune system identify which cells belong in your body and which do not. Sometimes called HLA matching, HLA typing can help identify when potential tissue donors are a good match for recipients. This improves the likelihood of a successful transplant.
Anti-HLA-ABC Antibodies | Invitrogen - Thermo Fisher Scientific
Our HLA-ABC monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit and Rat. These antibodies have been verified by Relative expression and Cell treatment to confirm specificity to HLA-ABC. Find the HLA-ABC antibody that fits your needs.
HLA Class I - SpringerLink
2017年1月1日 · The classical HLA class I and class II molecules (HLA-ABC and HLA-DR, DP, DQ, respectively) are cell-surface glycoproteins closely related in structure and function. HLA class I molecules consist of two polypeptide chains, a heavy chain of 340 amino acids encoded in chromosome 6, and a light non-polymorphic chain, β2-microglobulin (β2-m ...
HLA Gene May Predict if Cancer Immunotherapy Will Work
2022年1月27日 · The gene form, known as HLA-A*03, is found in 2% to 16% of the US population. If the findings are confirmed in further studies, doctors could use the gene as a marker to help decide if a patient should or shouldn’t take an immune checkpoint inhibitor, said the scientist who led the study, Mary Carrington, Ph.D., of NCI's Center for Cancer Research.
Analysis of HLA–ABC locus-specific transcription in normal tissues
2010年9月15日 · We developed a novel human leukocyte antigen HLA–ABC locus-specific quantitative real-time polymerase chain reaction (PCR) to determine the locus-specific gene expression of HLA–ABC in peripheral blood leukocytes (PBLs, n = 53), colon mucosa (n = 15), and larynx mucosa (n = 15).