Hammerhead ribozyme - Wikipedia
The hammerhead ribozyme is an RNA motif that catalyzes reversible cleavage and ligation reactions at a specific site within an RNA molecule. It is one of several catalytic RNAs (ribozymes) known to occur in nature.
The Hammerhead Ribozyme: Structure, Catalysis and Gene …
The hammerhead ribozyme has long been considered a prototype for understanding RNA catalysis, but discrepancies between the earlier crystal structures of a minimal hammerhead self-cleaving motif and various biochemical investigations frustrated attempt to understand hammerhead ribozyme catalysis in terms of structure.
The Hammerhead Ribozyme: A Long History for a Short RNA
Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner. The hammerhead ribozyme was the first reported and the most extensively studied member of this family.
The Hammerhead Ribozyme: A Long History for a Short RNA
Jan 4, 2017 · Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner. The hammerhead ribozyme was the first reported and the most …
Identification of Hammerhead Ribozymes in All Domains of Life …
May 5, 2011 · We have used a bioinformatics search strategy to identify many novel variants of hammerhead self-cleaving ribozymes, including examples from species in all three domains of life. New architectural features and novel catalytic core variants were identified, and the genomic locations of some hammerhead ribozymes suggest important biological ...
The Hammerhead Ribozyme: A Long History for a Short RNA
Jan 4, 2017 · Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner. The hammerhead ribozyme was the first reported and the most …
The hammerhead ribozyme: structure, catalysis, and gene …
The hammerhead ribozyme has long been considered a prototype for understanding RNA catalysis, but discrepancies between the earlier crystal structures of a minimal hammerhead self-cleaving motif and various biochemical investigations frustrated attempt to understand hammerhead ribozyme catalysis in …
Ribozymes: The hammerhead swings into action - Cell Press
Jul 2, 1998 · The hammerhead ribozyme, a self-cleaving RNA structure, has been the focus of intense study because of its small size — approximately 50 nucleotides — and the seemingly simple RNA cleavage reaction it performs.
The ubiquitous hammerhead ribozyme - PMC - PubMed Central …
The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-) cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three helices, two of which form essential tertiary interactions for fast self-scission under physiological conditions.
Hammerhead Ribozyme - an overview | ScienceDirect Topics
The hammerhead ribozyme is a small catalytic RNA that can catalyze a self-cleavage reaction. Hammerhead ribozymes take part in the replication of some viroids and satellite RNAs (Fig. 5.27). These both exist as single-stranded RNA genomes that form rod-like structures that are resistant to cellular ribonucleases.