Hemoperfusion: technical aspects and state of the art
2022年5月12日 · Background Blood purification through the removal of plasma solutes by adsorption to beads of charcoal or resins contained in a cartridge (hemoperfusion) has a long and imperfect history. Developments in production and coating technology, however, have recently increased the biocompatibility of sorbents and have spurred renewed interest in …
CytoSorb hemoperfusion markedly attenuates circulating cytokine ...
2023年3月21日 · CytoSorb hemoperfusion. The CytoSorb 300 mL hemoadsorption device (CytoSorbents Corporation, Princeton, New Jersey, USA) was placed into an extracorporeal circuit on a hemodialysis machine with a dedicated hemoperfusion blood line set (Gambro Prismaflex System and Gambro HP-X line set, Baxter, Deerfield, Illinois, USA).
Polymyxin B hemoperfusion: a mechanistic perspective
2014年6月9日 · Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridge (PMX-DHP) is an established strategy in the treatment of septic shock in Japan and parts of Western Europe. PMX-DHP is currently the subject of a pivotal North American randomized controlled trial (EUPHRATES) in patients with septic shock and confirmed endotoxemia, as measured by the …
Extracorporeal techniques for the treatment of critically ill patients ...
2018年10月25日 · Adsorption is performed in the form of hemoperfusion (HP), plasma perfusion, or coupled plasma filtration adsorption (CPFA) (detailed in the “Coupled plasma filtration adsorption (CPFA)” section). HP involves passage of blood through a hemofilter where mediators are adsorbed to the membrane surface or through a sorbent-containing cartridge.
Targeted therapy using polymyxin B hemadsorption in patients …
2023年6月21日 · Background Polymyxin B hemadsorption (PMX-HA) reduces blood endotoxin levels, but characteristics of patients with sepsis likely to benefit from PMX-HA are not well known. We sought to identify patient subgroups likely to benefit from PMX-HA. Methods We retrospectively identified 1911 patients with sepsis from a retrospective observational study in …
2022年4月25日 · Hemoperfusion: technical aspects and state of the art Claudio Ronco1,2,3 and Rinaldo Bellomo4,5,6,7,8* Abstract Background: Blood purication through the removal of plasma solutes by adsorption to beads of charcoal or resins contained in a cartridge (hemoperfusion) has a long and imperfect history. Developments in production and coating
The phenomenon of desorption: What are the best adsorber …
2024年5月27日 · To the Editor, With great interest we read the recent article in the Journal by Jansen et al. providing a proof-of-principle that treatment with CytoSorb ® hemoperfusion (HP) reduces plasma concentration of circulating cytokines in a model of systemic inflammation and that this reduction of circulating cytokines does not negatively affect the induction of endotoxin …
The effect of polymyxin B hemoperfusion on modulation of human ...
2018年10月26日 · The hemoperfusion was done with adsorbent columns consisting of 5 mg of polymyxin B per gram of polystyrene fiber (Toraymyxin ®; Toray Industries, Tokyo, Japan). Access to blood for PMX-HP treatment was obtained through a double-lumen catheter inserted into the central venous by Seldinger’s method.
Clinical review: Extracorporeal blood purification in severe sepsis
2003年2月21日 · 'Hemoperfusion' is a technique in which a sorbent is placed in direct contact with blood in an extracorporeal circuit. Nonspecific adsorbents, typically charcoal and resins, attract solutes through a variety of forces, including hydrophobic interactions, ionic (or electrostatic) attraction, hydrogen bonding, and van der Waals interactions.
Potential survival benefit of polymyxin B hemoperfusion in …
2017年6月7日 · Background The purpose of this study was to investigate whether polymyxin B hemoperfusion (PMX-HP) improves the survival of patients with septic shock. Methods This was a retrospective, multicenter study conducted on patients treated during a 3-year period. We performed propensity-score analyses of the Japan Septic Disseminated Intravascular …