Heteroplasmy - Wikipedia
Heteroplasmy is the presence of more than one type of organellar genome (mitochondrial DNA or plastid DNA) within a cell or individual. It is an important factor in considering the severity of mitochondrial diseases.
The dynamics of mitochondrial DNA heteroplasmy: implications
2015年8月18日 · Mitochondrial DNA (mtDNA) mutations have been associated with numerous human diseases, from severe inherited disorders to common late-onset diseases. In this Review, the authors consider the ...
Heteroplasmy - an overview | ScienceDirect Topics
Heteroplasmy is a condition where two or more different variants of mtDNA coexist within a cell. This can refer either to the presence of two normal variants, i.e. different healthy mtDNA haplotypes, or to the presence of healthy and mutated mtDNA in the same cell.
Heteroplasmy - an overview | ScienceDirect Topics
Heteroplasmy is the presence either in a cell, or more pertinently in a single individual of more than one type of mitochondrial genome. In the context of human ophthalmic disease, the term is used to refer to the presence in an individual patient …
Mitochondrial DNA heteroplasmy in human health and disease
Mitochondrial heteroplasmy may be defined as a dynamically determined co-expression of wild-type (WT)-inherited polymorphisms and somatic mutations in varying ratios within individual mtDNA genomes distributed throughout the intraorganelle compartments of individual cells.
Heteroplasmy and Individual Mitogene Pools: Characteristics and ...
Technically, heteroplasmy refers to the presence of more than one type of mitochondrial DNA (mtDNA) in an individual . Heteroplasmy is a copy-level mitogenome variation, and each cell, tissue, organ, and individual can be a reservoir of various variants .
Nuclear genetic control of mtDNA copy number and heteroplasmy …
2023年8月16日 · Heteroplasmy refers to the presence of a mixture of mtDNA alleles in an individual and has been associated with disease and ageing.
Heteroplasmy and Individual Mitogene Pools: Characteristics and …
2023年11月20日 · This review focuses on the characteristics, dynamics, and functions of mtDNA heteroplasmy and proposes the concept of individual mitogene pools to discuss individual genetic diversity from multiple angles.
Heteroplasmy: Definition, Role, Mechanism, Techniques
2023年7月14日 · Heteroplasmy is a genetic phenomenon referring to the presence of more than one type of mitochondrial DNA (mtDNA) within a cell or individual [1]. The term is derived from the words ‘hetero,’ meaning different, and ‘plasma,’ referring to the material in a living cell.
Heteroplasmy as a common state of mitochondrial genetic
2006年6月9日 · Heteroplasmy is defined as a state in which more than one mitochondrial genotype occurs in an organism. The ratio of different types of mtDNAs in a heteroplasmic population may be variable, but usually one mitotype is prevalent, while the alternative one (s) are present in a very low proportion.