IGFBP7 - Wikipedia
网页Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. [5][6][7] The major function of the protein is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as …
Insulin-like growth factor-binding protein-7 (IGFBP7) links
网页2022年12月22日 · IGFBP7 promoted cardiac senescence by stimulating IGF-1R/IRS/AKT-dependent suppression of FOXO3a, preventing DNA repair and reactive oxygen species (ROS) detoxification, thereby accelerating the...
IGFBP7：免疫治疗新靶点 - 知乎 - 知乎专栏
网页胰岛素样生长因子结合蛋白7（IGFBP7）是胰岛素超家族的生长促进肽成员，可与胰岛素和IGF结合，调控细胞生长和分化。 IGFBP7在不同的肿瘤类型中表现出抑制或促进肿瘤生长的“自相矛盾”活性。 研究发现IGFBP7可增强治疗性单克隆抗体的抗肿瘤作用，并在某些癌症血清中含量高，正在成为多种疾病诊断的生物标志物。 IGFBP7的生理学和病理学意义. IGFBP7在多种组织中表达，包括大脑、肝脏、胰腺和骨骼肌。 IGFBP7通过调节组织 …
IGFBP7 Gene - GeneCards | IBP7 Protein | IBP7 Antibody
网页2024年8月6日 · IGFBP7 (Insulin Like Growth Factor Binding Protein 7) is a Protein Coding gene. Diseases associated with IGFBP7 include Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis and Diabetic Angiopathy .
IGFBP：病理性疾病和癌症生物标志物 - 知乎 - 知乎专栏
网页2023年9月13日 · 在心力衰竭的动物模型中进行蛋白质组学分析，认为igfbp7是评估心力衰竭预后的潜在生物标志物。 总之，IGFBPs正在成为各种疾病的生物标志物，包括自身免疫性疾病、心衰和癌症。
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric …
网页2023年1月21日 · Mechanismly, IGFBP7 was highly expressed in cancer-associated fibroblasts (CAF) and mesenchymal cells, and was induced by epithelial-to-mesenchymal transition (EMT) signaling, since its...
IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation
网页2012年12月18日 · Insulin-like growth factor–binding protein 7 (IGFBP7) is a secreted factor that suppresses growth, and the abundance of IGFBP7 inversely correlates with tumor progression. Here, we showed that pret...
IGFBP7, a novel tumor stroma marker, with growth-promoting
网页2014年3月17日 · The putative TGFβ-target IGFBP7 was identified as a tumor stroma marker of epithelial cancers and as a tumor antigen in mesenchyme-derived sarcomas.
IGFBP7 and the Tumor Immune Landscape: A Novel Target for …
网页2022年6月23日 · Insulin-like growth factor binding protein-7 (IGFBP7) was recently reported to be a ligand of CD93, a potential target to normalize vasculature and attenuate immunotherapy. However, its role in the tumor microenvironment (TME) and immunotherapy response of bladder cancer (BLCA) remains unclear.
Insulin-Like Growth Factor-Binding Protein 7 (IGFBP-7)—New …
网页2022年5月17日 · The aim of our study was to evaluate the importance of insulin-like growth-factor-binding protein 7 (IGFBP-7) as a potential marker of symptomatic peripheral artery disease (PAD) occurrence. The study group consisted of 145 patients with diagnosed PAD, who qualified for the invasive treatment.
跳至内容