Incretin - Wikipedia
网页Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. Incretins are released after eating and augment the secretion of insulin released from pancreatic beta cells of the islets of Langerhans by …
Incretin hormones: Their role in health and disease - PubMed
网页Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate insulin secretion together with hyperglycaemia. GIP (glucose-dependent insulinotropic polypeptide) und GLP-1 (glucagon-like peptide-1) are the known incretin hormones from the upper (GIP, K cells) and lower (GLP ….
基于肠促胰素的血糖控制：未来 50 年的发展 - 丁香园
网页2015年6月23日 · 肠促胰素（Incretin）是一类在食物营养物质刺激下，由肠道内分泌细胞合成分泌的激素，可通过促进β细胞的胰岛素分泌、抑制α细胞不适当的胰升糖素分泌、延缓胃排空及抑制食欲等多个途径参与机体血糖稳态调节。. 在过去的十年里，基于肠促胰素的治疗药 …
The Role of Incretins in Glucose Homeostasis and Diabetes …
网页The insulin secretory response of incretins, called the incretin effect, accounts for at least 50% of the total insulin secreted after oral glucose. Therefore, by definition, incretin hormones are insulinotropic (i.e., they induce insulin secretion) at usual physiological concentrations seen in the plasma after ingestion.
The Role of Incretins on Insulin Function and Glucose Homeostasis
网页2021年3月30日 · The incretin effect—the amplification of insulin secretion after oral vs intravenous administration of glucose as a mean to improve glucose tolerance—was suspected even before insulin was discovered, and today we know that the effect is due to the secretion of 2 insulinotropic peptides, glucose-dependent insulinotropic polypeptide (GIP) …
The Origin and Understanding of the Incretin Concept
网页2018年7月16日 · Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy.
The emerging role of incretins and twincretins - Nature
网页2021年12月6日 · In 2021, clinical trials reported the promising effects of incretins and a new class of dual glucagon-like peptide 1–glucose-dependent insulinotropic peptide receptor agonists in preventing and...
The expanding incretin universe: from basic biology to clinical ...
网页Here we review evolving concepts of incretin action, focusing predominantly on GLP-1, from discovery, to clinical proof of concept, to therapeutic outcomes. We identify established vs uncertain mechanisms of action, highlighting biology conserved across species, while illuminating areas of active investigation and uncertainty that require ...
The expanding incretin universe: from basic biology to clinical ...
网页2023年3月28日 · Notably, the glucoregulatory and anorectic activities of GIP and GLP-1 have supported development of incretin-based therapies for the treatment of type 2 diabetes and obesity. Here we review evolving concepts of incretin action, focusing predominantly on GLP-1, from discovery, to clinical proof …
Illuminating the incretin effect - Nature
网页2021年6月17日 · The first significant incretin to be identified was the duodenal glucose-dependent insulinotropic polypeptide, GIP. In 1973, Dupre et al. demonstrated that infusion of GIP in combination with...
跳至内容