Interleukin-1 receptor antagonist - Wikipedia
Interleukin 1 receptor antagonist is used in horses for the treatment of equine lameness secondary to joint and soft-tissue injury. IL-1RA obstructs the IL1B inflammatory cascade rather than helping to restore damaged tissue.
Interleukin-1 receptor antagonist: From synthesis to therapeutic ...
Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture
THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE - PMC
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes 7 ligands with agonist activity (IL-1α and β, IL-18, IL-33, IL-36α, β, γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38) and an anti-inflammatory cytokine (IL-37).
The IL-1 family: regulators of immunity - Nature
2010年1月18日 · The interleukin-1 (IL-1) cytokine family comprises 11 members: IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33 and IL-1F5–IL-1F10.
Interleukin 1 inhibitors: Biology, principles of use, and adverse ...
2023年10月12日 · A related IL-1 family member, IL-1 receptor antagonist (IL-1ra), serves as an inhibitor that competes with both cytokines for binding to the receptor. IL-1R1 is expressed by most immune and nonimmune cells, accounting for the broad proinflammatory impact of IL-1.
IL-1 pathways in inflammation and human diseases - Nature
2010年2月23日 · The effects of IL-1 are tightly controlled by several naturally occurring inhibitors, such as IL-1 receptor antagonist (IL-1Ra), IL-1 receptor type II (IL-1RII), and other soluble...
Treating inflammation by blocking interleukin-1 in a broad …
The condition is called deficiency of interleukin-1 receptor antagonist (DIRA), and daily treatment with anakinra rapidly reverses the inflammation and prevents a lethal outcome.
Interleukin-1 (IL-1) Pathway | Science Signaling - AAAS
IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a number of human autoinflammatory diseases.
Overview of the IL-1 family in innate inflammation and acquired ...
Each member of the IL-1 receptor and TLR family contains the cytoplasmic Toll-IL-1-Receptor (TIR) domain. The 50 amino acid TIR domains are highly homologous with the Toll protein in Drosophila. The TIR domain is nearly the same and present …
Interleukin-1 receptor antagonist: role in biology - PubMed
The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from monocytes, macrophages, neutrophils, and ot …