Interleukin 8 - Wikipedia
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells [3] and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel–Palade bodies.
Interleukin - StatPearls - NCBI Bookshelf
2022年8月22日 · Interleukin-8 (IL-8) Monocytes and fibroblasts make IL-8. Its principal targets are neutrophils, basophils, mast cells, macrophages, and keratinocytes. It causes neutrophil chemotaxis, angiogenesis, superoxide release, and granule release. Interleukin-9 (IL-9) Th9, Th2, Th17, mast cells, NKT cells, and regulatory T cells produce this cytokine.
Interleukin 8 - an overview | ScienceDirect Topics
Interleukin-8 (IL-8) was the first member identified of a growing family (currently more than 40 members) of pro-inflammatory chemokines that attract and activate immune and inflammatory cells.
Interleukin-8: An evolving chemokine - ScienceDirect
2022年5月1日 · Interleukin 8 (monocyte-derived neutrophil chemotactic factor) dynamically regulates its own receptor expression on human neutrophils
The role of interleukin-8 in inflammation and mechanisms of
Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it has a distinct target specificity for the neutrophil, with only weak effects on other blood cells. Interleukin-8 attracts and activates neutrophils in inflammatory regi …
Interleukin-8: An evolving chemokine - PubMed
MDNCF was renamed interleukin 8 (IL-8) at the International Symposium on Novel Neutrophil Chemotactic Activating Polypeptides, London, UK in 1989. The discovery of IL-8 prompted us to also purify and molecularly clone the cDNA of MCAF/MCP-1 responsible for monocyte chemotaxis, and other groups to identify a large family of chemotactic cytokines ...
Interleukin 8 - an overview | ScienceDirect Topics
Interleukin-8 (IL-8) is one of the major mediators of the inflammatory response. It is secreted by several cell types and functions as a chemoattractant and as a potent angiogenic factor. It is similar to IL-6 but has a longer half-life.
Interleukin-8, a chemotactic and inflammatory cytokine
1992年7月27日 · Interleukin-8 (IL-8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin-1 or tumor necrosis factor) and activates neutrophils inducing chemotaxis, exocytosis …
IL-8 and cancer prognosis on immunotherapy | Nature Medicine
2020年5月11日 · Interleukin-8, produced by intratumoral and circulating myeloid cells, correlates with an immunosuppressive myeloid-enriched tumor microenvironment and adverse cancer prognosis.
Frontiers | The Role of Interleukin-8 in Lung Inflammation and …
2022年1月11日 · Interleukin 8 (IL-8) is a pro-inflammatory cytokine that has a role in neutrophil activation and has been identified within the pathogenesis and progression of this disease. The aim of this review is to highlight the role of IL-8 as a biomarker and prognostic factor in modulating the hyperinflammatory response in ARDS.