Isoxazole - Wikipedia
Isoxazole is an electron-rich azole with an oxygen atom next to the nitrogen. It is also the class of compounds containing this ring. Isoxazolyl is the univalent functional group derived from isoxazole.
The main directions and recent trends in the synthesis and use of ...
2020年7月23日 · This review summarizes the main directions and recent trends in the synthesis of isoxazoles, and also provides examples of the use of isoxazoles as biologically active compounds in medicinal chemistry. When discussing the classical methods of isoxazole synthesis, the main emphasis is placed on the problem of selectivity of transformations.
An overview of metal-free synthetic routes to isoxazoles: the ...
In the field of drug discovery, isoxazole is a five-membered heterocyclic moiety commonly found in many commercially available drugs. In view of their enormous significance, it is always imperative to unleash new eco-friendly synthetic strategies.
Isoxazole - NIST Chemistry WebBook
Formula: C 3 H 3 NO. Molecular weight: 69.0620. IUPAC Standard InChI:InChI=1S/C3H3NO/c1-2-4-5-3-1/h1-3H Copy. IUPAC Standard InChIKey:CTAPFRYPJLPFDF-UHFFFAOYSA-N Copy. CAS Registry Number: 288-14-2.
The synthetic and therapeutic expedition of isoxazole and its …
2018年2月27日 · The present review demonstrates the synthesis and structural modifications of isoxazoles. Isoxazole is a versatile building block in many biologically active compounds, and its easy synthesis offers the structure activity studies of various substitutions on this pharmacophore as illustrated in Table 2. This review is endeavoring to find ...
Isoxazoles: synthesis, evaluation and bioinformatic design as ...
2013年12月1日 · The isoxazole is an azole with an oxygen atom bonded to a nitrogen atom; these compounds are an important category of five-membered unsaturated heterocyclic compounds. They show numerous applications in diverse areas such as pharmaceuticals, agro-chemistry and industry among others.
oxazoles, anthranils, and other polynuclear isoxazole derivatives, as well as the tabular survey, an updating of Part I, and a chapter on applications of isoxazole compounds, will be provided.
Isoxazole, constituting an important family of five-membered heterocycles with one oxygen atom and one nitrogen atom at adjacent positions is of immense importance because of its wide spectrum of biological activities and therapeutic potential.
Isoxazole/Isoxazoline Skeleton in the Structural Modification of
2023年2月2日 · Isoxazole is a heterocyclic compound with a five-membered ring that has oxygen and nitrogen atoms at the 1 and 2 positions, and their partially saturated analogs are known as isoxazoline. Many biologically active products contain derivatives of these heterocyclic compounds [1,2,3].
Isoxazole synthesis - Organic Chemistry Portal
Various 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in good yields by the reaction of N -hydroxyl-4-toluenesulfonamide with α,β-unsaturated carbonyl compounds. This strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope. S. Tang, J. He, Y. Sun, L.