How the amino acid leucine activates the key cell-growth regulator mTOR
2021年7月21日 · The amino acid leucine is a potent stimulator of mTORC1: it blocks the inhibitory effect of the protein sestrin 2 on the GATOR2 complex that activates mTORC1 4. Such regulation links the...
SAR1B senses leucine levels to regulate mTORC1 signalling
2021年7月21日 · The mTOR complex 1 (mTORC1) controls cell growth in response to amino acid levels 1. Here we report SAR1B as a leucine sensor that regulates mTORC1 signalling in response to intracellular...
Sestrin2 is a leucine sensor for the mTORC1 pathway - PubMed
2016年1月1日 · Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller. Amino acids signal to mTORC1 through the Rag guanosine triphosphatases (GTPases).
The actions of exogenous leucine on mTOR signalling and amino …
2011年6月25日 · The branched-chain amino acid (BCAA) leucine has been identified to be a key regulator of skeletal muscle anabolism. Activation of anabolic signalling occurs via the mammalian target of rapamycin (mTOR) through an undefined mechanism.
How the amino acid leucine activates the key cell-growth regulator mTOR ...
How the amino acid leucine activates the key cell-growth regulator mTOR. Nature. 2021 Aug;596 (7871):192-194. doi: 10.1038/d41586-021-01943-7.
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
2019年1月8日 · The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this context.
A leucine-rich diet modulates the mTOR cell signalling pathway in …
2019年4月11日 · Meanwhile, the leucine-rich diet modulated key steps of the mTOR pathway by triggering the increased activation of RAG and mTOR and maintaining JNK, STAT-3 and STAT-6 levels in muscle, leading to an increased muscle protein synthesis, reducing the degradation during tumour evolution in a host, minimising the cancer-induced damages in the ...
Leucine regulates autophagy via acetylation of the mTORC1 ... - Nature
2020年6月19日 · While leucine (Leu) is a critical mTORC1 regulator under AA-starved conditions, how Leu regulates autophagy is poorly understood. Here, we describe that in most cell types, including neurons, Leu...
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
2019年1月8日 · The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this context. Here we describe that the Leu metabolite acetyl-coenzyme A (AcCoA) positively regulates mTORC1 activity by EP300 ...
Differential regulation of mTORC1 by leucine and glutamine
Leucine (Leu) (2, 4, 5), glutamine (Gln) (5–7), and arginine (Arg) have been implicated in mTORC1 activation. In one model, mTORC1 indirectly senses amino acids within the lysosomal lumen that requires the Rag guanosine triphosphatases (GTPases), which are regulated by the pentameric Ragulator complex, the vacuolar H + –adenosine ...