Airway ciliated cells in adult lung homeostasis and COPD
Pulmonary cilia include motile cilia lining the epithelial cells of the conductive airways to orchestrate mucociliary clearance, and primary cilia found on nondifferentiated epithelial and …
A Periciliary Brush Promotes the Lung Health by Separating
2012年8月24日 · We propose a gel-on-brush model in which the periciliary layer is occupied by membrane-spanning mucins and mucopolysaccharides densely tethered to the airway …
Development of a Primary Human Co-Culture Model of Inflamed …
2017年8月15日 · Neutrophil transepithelial migration studies are traditionally conducted by using lung epithelial cell lines to produce inverted polarized monolayers that serve to...
Cilia and Models for Studying Structure and Function
2011年9月9日 · From the flagella that propel the sperm and the cilia that transport the egg through the fallopian tube, to the nodal cilia that determine the left-right axis, to the respiratory …
Muco-ciliary transport in the lung - ScienceDirect
1986年8月21日 · A simplified version of the traction layer approach has been used to model muco-ciliary transport in the lung (Blake & Winet, 1982) although this model uses only an …
Seeing cilia: imaging modalities for ciliary motion and clinical ...
In this review, we provide an overview of ciliary motion, imaging modalities, and ciliopathic diseases of the respiratory system including primary ciliary dyskinesia, cystic fibrosis, chronic …
Altered generation of ciliated cells in chronic obstructive pulmonary ...
2019年11月29日 · Surgical lung tissue from 81 COPD and 61 control (smokers and non-smokers) patients was assessed for bronchial epithelial cell phenotyping by immunohistochemistry, both …
CYLD/HDAC6 signaling regulates the interplay between epithelial ...
2024年8月9日 · Mechanistic study reveals that downregulation of CYLD underlies the crosstalk between EMT and ciliary homeostasis by inactivating histone deacetylase 6 (HDAC6) during …
Engineering rotating apical-out airway organoid for assessing ...
2022年8月19日 · Airway organoids engineered from patient stem cells are a promising model for investigating respiratory pathophysiology, including ciliopathies. The airway epithelium is …
The Evolving Spectrum of Ciliopathies and Respiratory Disease
Research on the biology of cilia, complex hair-like cellular organelles, has greatly informed our understanding of its crucial role in respiratory health and the pathogenesis of Primary Ciliary …