Mitogen-activated protein kinase - Wikipedia
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines.
A Comprehensive Review on MAPK: A Promising Therapeutic …
2021年10月22日 · The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic ...
MAPK/ERK pathway - Wikipedia
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
Mitogen-activated protein kinase kinase - Wikipedia
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK). MAP2K is classified as EC 2.7.12.2. There are seven genes:
The MAPK cascades: Signaling components, nuclear roles and …
2011年9月1日 · The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response.
The roles of MAPKs in disease | Cell Research - Nature
2008年3月18日 · In this review we present some background on MAPK pathways and then discuss key findings that suggest mechanisms that may link MAPKs to specific diseases.
Understanding MAPK Signaling Pathways in Apoptosis - PMC
We also describe the basic signaling properties of MAPKs (ultrasensitivity, hysteresis, digital response), and the presence of different positive feedback loops in apoptosis. We provide a simple guide to predict MAPKs’ behavior, based on the intensity and duration of the stimulus.
Integrated molecular characterisation of the MAPK pathways in …
2021年1月4日 · The mitogen-activated protein kinase (MAPK) pathways are crucial regulators of the cellular processes that fuel the malignant transformation of normal cells.
Mitogen-Activated Protein Kinase (MAPK) Signaling
2018年12月7日 · The mitogen-activated protein kinases (MAPKs) have been under careful investigation for a long period, and this signaling pathway is one of the most studied. MAPKs regulate cell proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis....
Activation and Function of the MAPKs and Their Substrates, the MAPK …
Summary: The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by relaying extracellular signals to intracellular responses. In mammals, there are more than a dozen MAPK enzymes that coordinately regulate cell proliferation, differentiation, motility, and survival. The best known are the conventional MAPKs, which ...