基质金属蛋白酶（MMPs）种类及功能 - 知乎 - 知乎专栏
网页本文介绍了基质金属蛋白酶（MMPs）的结构特点、细胞来源、细胞学功能和调控机制，以及MMP-1在胶原水解、炎症和疾病中的作用。MMP-1是一种胶原酶，可降解ECM的胶原蛋白，参与组织修复、炎症和疾病的发生和发 …
Interstitial collagenase - Wikipedia
Interstitial collagenase, also known as fibroblast collagenase and matrix metalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP-1 was the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA. MMP-1 has an estimated molecular mass of 54 kDa.
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Structure and Function of Human Matrix Metalloproteinases
网页2020年4月26日 · MMP-1 cleaves pro-MMP-2 and -9 into its active form. MMP-1 expression is increased by inflammatory cytokines (TNF-α and IL-1). 8: Collagenase-2; Neutrophil …
The Roles of Matrix Metalloproteinases and Their Inhibitors in …
网页2020年12月20日 · Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to …
MMP-1: the elder of the family - PubMed
网页Human fibroblast collagenase (MMP-1) was the first vertebrate collagenase purified as a protein and cloned as a cDNA, and is considered the prototype for all the interstitial …
Physiology and pathophysiology of matrix metalloproteases
网页2010年7月18日 · MMP-1 or collagenase-1 was the first described matrix metalloprotease and has sparked a large volume of research on the physiological and pathological role of …
Activity-dependent interdomain dynamics of matrix …
网页2020年11月26日 · Interdomain dynamics of MMP1 on fibrin correlates with activity. More than 300,000 smFRET values at 22 °C with a 100 ms time resolution for each condition …
Matrix metalloproteinases in arthritis: towards precision medicine
网页2023年5月9日 · MMP-1 (collagenase) and MMP-3 (stromelysin-1) are also detected in synovial fluid and in cartilage tissue 54 and might be involved in local inflammation of …
An in vitro investigation to understand the synergistic role of …
网页2021年7月13日 · MMP-1 (c) and MMP-9 (g) have exhibited their destructive ability to denature and digest collagen fibrils at the molecular level 19, whereas the current study …
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