Macrophages in immunoregulation and therapeutics
2023年5月22日 · Herein, we discuss immune regulation in macrophage polarization and signaling, mechanical stresses and modulation, metabolic signaling pathways, mitochondrial and transcriptional, and epigenetic...
Alter macrophage adhesion and modulate their response on ...
2021年1月15日 · Adhesion of macrophages to material substrates plays an essential role in many biological behaviors and biomedical procedures, including wound healing, cancer treatment and biomaterial implantation. Therefore, altering the adhesion of macrophages using biomaterial design may help control their biological function.
Physical and mechanical regulation of macrophage phenotype …
Macrophage adhesion to the extracellular matrix environment is mediated by various types of integrins, as well as scavenger receptors. Interestingly, macrophages have been known to deploy different modes of adhesion to type collagen I that may be dependent on species, cell source, or the context of adhesion.
Macrophages modulate stiffness-related foreign body responses ... - PNAS
In this study, we demonstrated that macrophages can influence intracellular curvature-sensing proteins through an adhesion-mediated plasma membrane deformation mechanism, which in turn regulates cytoskeletal remodeling in response to stiffness.
The Molecular Mechanism of Macrophages in Response to
2024年10月1日 · During phagocytosis, macrophages utilize tyrosine kinase signaling to assemble mechanosensitive, talin- and vinculin-mediated, focal adhesion-like molecular clutch, coupling integrins to cytoskeletal forces to facilitate particle engulfment .
Immunoregulation of macrophages by dynamic ligand …
2019年4月12日 · Abstract. Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP)...
Surgical adhesions: A sticky macrophage problem | Science - AAAS
2021年3月5日 · In response to surgical insult, these macrophages act like platelets to form superaggregates, which then develop into adhesions. A fascinating parallel exists with invertebrates whereby body-cavity macrophages express evolutionarily ancient receptors, which may be potential targets for adhesion prevention.
Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular ... - PubMed
2019年5月14日 · We define a macrophage-dependent signaling cascade that facilitates metastasis through lymphovascular remodeling. TNBC cells instigate mRNA changes in macrophages, resulting in β4 integrin-dependent adhesion to the lymphovasculature. β4 integrin retains macrophages proximal to lymphatic endothelial cells (LECs), where release of TGF-β1 ...
Switch of macrophage fusion competency by 3D matrices
2020年6月25日 · Our results demonstrate that the 3D matrix-induced fusogenic stimuli alter the cell state of macrophage in three aspects: 1) the cytoskeleton (F-actins, Fig. 2B), 2) the cell-matrix adhesion ...
Integrin-Mediated Macrophage Adhesion Promotes …
2019年5月14日 · We propose that macrophages have an important role in controlling established tumoral lymphatic networks in TNBC and that lymphatic dissemination of cancer cells is facilitated by a cascade of signaling events initiated by integrin-mediated adhesion of macrophages at the sites of lymphatic vessels.