Small but mighty: the causes and consequences of micronucleus …
2020年11月24日 · Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the main nucleus. They are frequently found in pathologies, including cancer. It …
Epigenetic dysregulation from chromosomal transit in micronuclei
2023年6月7日 · Gene-set enrichment analysis (GSEA) revealed that genes that were preferentially accessible in micronuclei as opposed to primary nuclei were involved in …
A p62-dependent rheostat dictates micronuclei catastrophe and …
We isolated micronuclei and primary nuclei, analyzed their protein composition using mass spectrometry, and identified p62/SQSTM1—a key autophagic pathway component—as …
Micronuclei induced by radiation, replication stress, or …
2024年6月6日 · Recent studies have suggested that micronuclei formed by genotoxic stress can activate innate immune signaling via the cGAS-STING pathway. Here, we investigated cGAS …
Heritable transcriptional defects from aberrations of nuclear ...
2023年6月7日 · Defective transcription from both intact and ruptured micronuclei was confirmed by fluorescence intensity (FI) measurements for a marker of active, phosphorylated RNA …
Micronuclear collapse from oxidative damage | Science - AAAS
Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear …
Alerting the immune system to DNA damage: micronuclei as …
2020年8月26日 · Micronuclei can initiate pro-inflammatory signaling cascades, or massively degrade to invoke distinct forms of genomic instability. In this mini-review, we aim to provide …
The Interplay Between the DNA Damage Response, RNA …
2020年1月17日 · Damaged cancer cells secrete type I interferons and proinflammatory cytokines transcriptionally activated by IRF3 or NFB. The cytosolic damaged DNA from micronuclei can …
Causes and consequences of micronuclei - PMC
Micronuclei are small membrane bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have long …
Micronuclei as biomarkers of DNA damage, aneuploidy, inducers …
2020年10月1日 · Micronuclei (MNi) are a biomarker of chromosomal damage and instability in humans. Causes and consequences of MNi formation can be elucidated using molecular …
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