The NK cell checkpoint NKG2A maintains expansion capacity of …
2023年6月29日 · NKG2A/CD94 is an inhibitory receptor on NK cells that has established regulatory functions in the direct interaction with target cells when engaged with its ligand, the non-classical HLA...
The NKG2A immune checkpoint — a new direction in cancer ... - Nature
2019年3月1日 · The interaction of peptide-loaded HLA-E on tumour cells with NKG2A–CD94 on CD8 + T cells results in phosphorylation of the cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs) of...
Implications of NKG2A in immunity and immune-mediated diseases
In recent studies, NKG2A is revealed to be a key immune checkpoint for both natural killer (NK) cells and CD8 + T cells. It form heterodimer receptors with CD94, and targets the peptide-presenting human leukocyte antigen-E (HLA-E) molecules.
NKG2A, a New Kid on the Immune Checkpoint Block - Cell Press
2018年12月13日 · NKG2A is a cell surface molecule, which is typically expressed by NK cells, but expression can be induced on T cells as well, especially on CD8 + T cells. NKG2A belongs to a family of lectins, which forms a heterodimer with CD94, also known as KLRD1, another NK cell expressed C-type lectin.
Unlocking the therapeutic potential of the NKG2A-HLA-E immune ...
The non-classical major histocompatibility complex (MHC) class-I molecule, HLA-E, is the predominant ligand for the CD94/NKG2A receptor,12 which is widely expressed on different cells at low levels and upregulated in many cancer types.13 Binding of CD94/NKG2A to its cognate ligand HLA-E inhibits immune activity,14 and helps to prevent the ...
NKG2A/CD94 Is a New Immune Receptor for HLA-G and …
As already described for NKG2A/CD94 expression and HLA-E-positive tumors, downregulation or blocking of NKG2A/CD94 enhances the antitumor function of NK cell infusions . This might be even more important in the light of HLA-G interacting with NKG2A/CD94 since HLA-G-expression is independent of the expression of other HLA molecules.
The role of CD94/NKG2 in innate and adaptive immunity
The level of CD94 expression is inversely correlated with the level of apoptosis in culture. Thus, CD94/NKG2 receptors may regulate effector functions and cell survival of NK cells and CD8 T cells, thereby playing a crucial role in the innate and adaptive immune response to a pathogen.
NKG2A/CD94 Is a New Immune Receptor for HLA-G and
2020年6月19日 · NKG2A/CD94 could be confirmed as an immune receptor of HLA-G*01:01. Despite HLA-G is marginal polymorphic, we could previously demonstrate that the most common allelic subtypes HLA-G*01:01/01:03 and 01:04 differ in peptide repertoire, their engagement to NK cells, their catalyzation of dNK cell proliferation and their impact on NK cell development.
Monalizumab is a first in class humanized IgG4 antibody with sustained, dose dependent occupancy of NKG2A–CD94, thereby preventing its inter action with HLA E. By blocking NKG2A– CD94 signalling,...
NKG2A is a late immune checkpoint on CD8 T cells and marks
2022年2月15日 · The surface inhibitory receptor NKG2A forms heterodimers with the invariant CD94 chain and is expressed on a subset of activated CD8 T cells. As antibodies to block NKG2A are currently tested in several efficacy trials for different tumor indications, it is important to characterize the NKG2A + …
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