NS-398, a new anti-inflammatory agent, selectively inhibits ... - PubMed
NS-398 is a novel anti-inflammatory and analgesic agent which produces much fewer gastrointestinal lesions in rats. Recently, two forms of cyclooxygenase have been identified: a COX-1 first purified from ram seminal vesicles and a …
Cyclooxygenase-2 selective inhibition with NS-398 suppresses …
2004年2月3日 · NS-398 (100 μ M), a highly selective COX-2 inhibitor, decreased cell proliferation by ∼ 35% of control, as determined using [3 H]-thymidine incorporation. This reduction in cell...
The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and ...
The present study aimed to investigate the expression and clinical significance of COX-2 and survivin (SUV) in human osteosarcomas (OS), and explore the effects and molecular mechanisms of a selective COX-2 inhibitor NS-398 and SUV on tumor proliferation and apoptosis.
Cyclooxygenase-2 Inhibitor NS-398 Protects Neuronal Cultures …
2001年10月1日 · The COX-2 inhibitor NS-398 blocks PGE 2 production and markedly ameliorates LPS-induced neuronal damage. Furthermore, NS-398 attenuates the increase in tumor necrosis factor-α (TNF-α), a cytokine involved in LPS-induced neuronal damage.
NS-398: Uses, Interactions, Mechanism of Action - DrugBank Online
NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases.
NS-398, a Cyclooxygenase-2-Specific Inhibitor, Delays Skeletal …
Here we examined the effects of NS-398, a Cox-2-specific inhibitor, both on myogenic precursor cells in vitro and in a mouse skeletal muscle laceration model in vivo. The administration of NS-398 inhibited the proliferation and maturation of differentiated myogenic precursor cells in vitro.
THE STRUCTURE OF NS-398 BOUND TO CYCLOOXYGENASE-2
N- (2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide (NS-398) was the first in a series of isoform-selective drugs designed to preferentially inhibit COX-2, with the aim of ameliorating many of the toxic gastrointestinal side effects caused by conventional NSAID inhibition.
Selective COX-2 inhibitor, NS-398, suppresses cellular …
2007年2月2日 · AIM: To investigate the growth inhibitory mechanism of NS-398, a selective cyclooxygenase-2 (COX-2) inhibitor, in two hepatocellular carcinoma (HCC) cell lines (HepG2 and Huh7). METHODS: HepG2 and Huh7 cells were treated with NS-398.
NS-398 | C13H18N2O5S | CID 4553 - PubChem
NS-398 is a C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2. It has a role as a cyclooxygenase 2 inhibitor and an antineoplastic agent.
NS-398, a selective COX-2 inhibitor, inhibits proliferation of IL …
2008年11月28日 · NS-398 reduced the production of PGE 2 without modulation of expression of COX-2 in IL-1β-stimulated VSMC. NS-398 increased HO-1 mRNA and protein in a dose-dependent manner, but inhibited proliferation of IL-1β-stimulated VSMC.
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