经典信号通路总结——Notch信号通路 - 知乎 - 知乎专栏
Notch 通路主要由四部分组成：Notch受体、Notch配体、CSLDNA结合蛋白、下游靶基因。上述四部分中任何一个因素改变都会对Notch信号通路传递产生影响。 相邻细胞间通过Notch受体传递信号，可以调节细胞的分化，增殖和凋亡。
Notch signaling pathway - Wikipedia
This releases the intracellular domain of the notch protein (NICD), which then moves to the nucleus, where it can regulate gene expression by activating the transcription factor CSL. It was originally thought that these CSL proteins suppressed Notch target transcription.
Notch 信号转导 - Cell Signaling Technology (CST)
Study the intricate Notch signaling pathway and its impact on cell fate determination and development. Click here to learn more. Notch 信号转导通路 | Cell Signaling Technology
Notch signaling pathway: architecture, disease, and therapeutics
2022年3月24日 · Once NICD enters the nucleus, it can bind with CSL and recruit MAMLs, releasing corepressors, recruiting coactivators, and thus promoting the transcription of NOTCH target genes.
Targeting Notch in oncology: the path forward - Nature
2020年12月8日 · Binding to transmembrane ligands from neighbouring cells results in receptor subunit separation and proteolytic cleavage of the transmembrane subunit to release a Notch intracellular domain...
Notch signaling pathway in cancer: from mechanistic insights to ...
2024年5月27日 · This review focuses on the research progress of the Notch signaling pathway in cancers, providing in-depth insights into the potential mechanisms of Notch signaling regulation in the occurrence...
Notch intracellular domain regulates glioblastoma proliferation through ...
Notch intracellular domain (NICD), also known as the activated form of Notch1 is closely associated with cell differentiation and tumor invasion. However, the role of NICD in glioblastoma (GBM) proliferation and the underlying regulatory mechanism remains unclear.
Mechanical regulation of the Notch signaling pathway
2023年12月1日 · Finally, we discuss the mechanoregulation of the Notch intracellular domain (NICD) trafficking and nuclear entry and the impact of mechanical stress on heterochromatin dynamics and nuclear NICD interactions.
A spatially defined human Notch receptor interaction network …
Due to the “one-on-one” activation mode, the Notch signaling intensity depends strongly on the production of NICD. When mature NOTCH was hydrolyzed into NICD, the signal turned on. However, each mature NOTCH protein can be hydrolyzed and activated only once.
Regulation of Notch Signaling Activity - ScienceDirect
2004年2月3日 · GSK3β has been shown to phosphorylate NICD in vitro and inhibition of GSK3β decreased the stability of NICD and reduced Notch receptor signaling [93]. Thus, GSK3β-mediated phosphorylation appears to stabilize NICD and potentiate its activity.