Nifedipine - StatPearls - NCBI Bookshelf
2023年5月23日 · Immediate-release preparations have an onset of action within 20 minutes with a plasma half-life of about 4 to 7 hours. Extended-release preparations have an approximate duration of action of about 24 hours. It undergoes hepatic metabolism via the CYP3A4 pathway.
Safety of Immediate-Release Nifedipine - PubMed
Nifedipine immediate release (IR) is a short-acting dihydropyridine calcium channel blocker historically used for hypertensive crisis, but its use has decreased because of reports of adverse reactions such as myocardial infarction (MI), arrhythmias, and stroke.
Safety of Nifedipine in Patients With Hypertension
1997年7月1日 · The results of our meta-analysis lend support to the safety of sustained-release and extended-release formulations of nifedipine in the treatment of hypertension, especially when they are used in combination with diuretics or β-blockers.
Nifedipine Dosage Guide + Max Dose, Adjustments - Drugs.com
2024年2月20日 · Immediate-release capsules: Initial dose: 10 mg orally 3 times a day. Maintenance dose: 10 to 30 mg orally 3 to 4 times a day. Maximum doe: 180 mg/day. Extended-release tablets: Initial dose: 30 to 60 mg orally once a day. Maintenance dose: 30 to 90 mg orally once a day. Maximum dose: Up to 120 mg/day. Comments:
PROCARDIA (nifedipine) is indicated for the management of vasospastic angina confirmed by any of the following criteria: 1) classical pattern of angina at rest accompanied by ST segment...
Efficacy and Safety of Immediate-Release Nifedipine in Critically …
2022年2月14日 · Background: Immediate-release nifedipine (IRN) is a calcium channel blocker with potent vasodilatory and antihypertensive properties. Safety concerns led to a black box warning for increased risk of myocardial infarction, stroke, and arrhythmias.
Guide to Nifedipine Dosages: How Much Should I Take? - GoodRx
2023年12月4日 · For angina and high blood pressure, the dosage for nifedipine extended-release (ER) tablets ranges from 30 mg to 120 mg once daily. For angina, the dosage for the immediate-release (IR) capsules ranges from 10 mg to 30 mg three or four times a day.
Efficacy and Safety of Immediate-Release Nifedipine in
Background: Immediate-release nifedipine (IRN) is a calcium channel blocker with potent vasodilatory and antihypertensive properties. Safety concerns led to a black box warning for increased risk of myocardial infarction, stroke, and arrhythmias.
Safety of Nifedipine in Angina Pectoris | Hypertension - AHA/ASA …
1999年1月1日 · Episodes of increased angina were more frequent on immediate-release nifedipine (OR, 4.19 [95% CI, 1.41 to 12.49]) and on nifedipine monotherapy (OR, 2.61 [95% CI, 1.30 to 5.26]).
Nifedipine Monograph for Professionals - Drugs.com
Conventional (immediate-release) nifedipine formulations generally are contraindicated in the routine management of acute MI because of negative inotropic effects and reflex sympathetic activation, tachycardia, and hypotension associated with its use.