Rink Amide resin (100-200 mesh) Novabiochem® | Sigma-Aldrich
An excellent support for the Fmoc SPPS of peptide amides. This resin is more acid-sensitive than Rink Amide AM and Rink Amide MBHA resins. Cleavage with high concentrations of TFA can lead to the breakdown of the linker, with the concomitant formation of by-products that can not be removed by simple washes.
Rink Amide Resin, PS, is a gel-type polystyrene resin and is the preferred support for solid phase synthesis of peptide amides utilizing Fmoc chemistry. It requires removal of the Fmoc protecting group prior to use, but once the amine is free, it is fully capable of generating primary carboxamides and sulfonamides via solid supported synthesis.
Rink Amide MBHA resin (100-200 mesh) - MilliporeSigma
This support comprises the modified Rink amide linker attached via norleucine to MBHA resin, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide …
Rink Amide ProTide Resin - CEM Corporation
A powerful rink amide resin that contains an ideal PEG and polystyrene core leading to an optimized SPPS environment. Unmatched performance for routine synthesis of long (> 30 amino acids) or difficult peptide amides.
Rink Amide ProTide Resin (LL) - CEM Corporation
A powerful rink amide resin that contains an ideal PEG and polystyrene core leading to an optimized SPPS environment. Unmatched performance for routine synthesis of long (> 30 amino acids) or difficult peptide amides.
Greening the synthesis of peptide therapeutics: an industrial ...
The synthesis of Aib-enkephalin on Rink Amide ChemMatrix® resin resulted in a much higher purity when using 2-MeTHF for couplings (81.9% and 95.0%, methods 2 and 5) instead of DMF (53.0%, method 1), while employing IPA for washings and deprotection (method 3) gave the worst outcome (30.8%).
Rink Amide AM resin (100-200 mesh) Novabiochem 183599-10 …
General description. This support comprises the modified Rink amide linker attached to aminomethylpolystyrene and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities. Associated Protocols and Technical Articles.
APExBIO - Rink Amide Resin|Cas # 13653-84-4 - apexbt.com
Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides. Libaries of primary amines have been synthesized by the treatment of Rink amine resin with aldehyde to form aldimines, which are subsequently reacted with Grignard ...
Fmoc SPPS Linkers - MilliporeSigma
Sieber Amide resin offers the most practical route to protected peptide amides. The C -terminal amino acid is loaded on the resin using standard coupling methods. Treatment with 1% TFA in DCM releases the protected peptide amide.
Solid-phase peptide synthesis. (A) Structure of Rink Amide AM …
The present review focuses on site-directed mutation, truncation, hybridisation, capping, and cyclisation of AMPs. The review further introduces the application of solid-phase peptide synthesis ...