A review on bacterial resistance to carbapenems: epidemiology ...
网页2020年1月27日 · Resistance to carbapenems may be attributed to three major mechanisms: porin-mediated resistance to reduce uptake of carbapenems, efflux pumps, which pump the carbapenem outside the cells and enzyme-mediated resistance which is mediated via the acquisition of carbapenemase genes.
Antibiotic Susceptibility Patterns for Carbapenem-Resistant ...
网页2023年2月20日 · Abstract. Carbapenem is a broad-spectrum beta-lactam antibiotic considered the last choice for the treatment of antibiotic-resistant Gram-negative bacteria. Thus, the increasing rate of carbapenem resistance (CR) in Enterobacteriaceae is an urgent public health threat. This study aimed to evaluate the antibiotic susceptibility pattern of ...
Guidelines for the prevention and control of carbapenem …
网页2017年11月1日 · Carbapenem-resistant gram-negative bacteria, namely, carbapenem-resistant Enterobacteriaceae (CRE), Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPsA), are an emerging cause of HAI …
Resensitizing carbapenem- and colistin-resistant bacteria to
网页2020年10月16日 · Global emergence of Gram-negative bacteria carrying the plasmid-borne resistance genes, blaMBL and mcr, raises a significant challenge to the treatment of life-threatening infections by the...
Allergic cross-sensitivity between penicillin, carbapenem, and ...
网页Data synthesis: Many patients have reported penicillin allergies that have not been verified by skin testing; many healthcare providers avoid the use of other beta-lactam antibiotics, namely carbapenems, in these patients due to fear of the potential for immunoglobulin E-mediated allergic cross-reactivity.
Overview and Insights into Carbapenem Allergy - PMC
网页2019年8月8日 · Understanding antibiotic allergies and the risk of cross-sensitivity between and within antibiotic classes can have a substantial impact on patient care. The purpose of this review article is to provide insight into carbapenem allergies, describing the overall incidence, risk factors, and in-class cross-sensitivity.
Diagnosis and Treatment of Carbapenemase-Producing …
网页2019年7月23日 · Carbapenem-producing organisms (CPO) have become important clinical pathogens in nosocomial infections causing increases in hospital stay, mortality, and costs. We sought to summarize recent findings related to the commonly encountered types of carbapenemases and their detection and review recent …
Distribution and molecular characterization of carbapenemase …
网页2024年6月22日 · Carbapenem antibiotics are a class of β-lactam antibiotics with a broad antimicrobial spectrum, vigorous antimicrobial activity, stability to β-lactamases, and low toxicity. They are regarded...
Cell morphology as biomarker of carbapenem exposure
网页2024年6月12日 · This study investigated the effect of increasing imipenem concentrations on carbapenem-susceptible (S) and carbapenem-resistant (R) E. coli on their growth adaptation and cell surface structure.
Medical Sciences | Free Full-Text | Carbapenem Resistance: A …
网页Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by transferable carbapenemase-encoding genes.
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