Signaling pathways in cancer metabolism: mechanisms and …
2023年5月10日 · Metabolite sensing can be achieved in three ways: metabolite sensor-mediated signal transduction, a metabolic sensing module, and conjugate sensing. Metabolite sensors are biological...
Signaling Pathways in Cancer: Therapeutic Targets, …
2021年3月16日 · Here we provide an up-to-date review of the successes and limitations of current targeted therapies for cancer treatment and highlight how recent technological advances have provided a new level of understanding of the molecular complexity underpinning resistance to cancer therapies.
Oncogenic Signaling Pathways in The Cancer Genome Atlas - Cell …
Several important signaling pathways have been identified as frequently genetically altered in cancer, including the RTK/RAS/MAP-Kinase (hereafter also called RTK-RAS for brevity) pathway, PI3K/Akt signaling, and others (Vogelstein and Kinzler, 2004).
Key signal transduction pathways and crosstalk in cancer: …
Cell signal transduction is a fundamental process in the development and progression of cancer. The mitogen-activated protein kinase (MAPK) pathway comprises several key signaling components and phosphorylation events that play crucial roles in tumorigenesis.
Inflammation and tumor progression: signaling pathways and …
2021年7月12日 · In this review, we discuss the initiation and resolution of inflammation, crosstalk between tumor development and inflammatory processes, as well as cancer therapeutic approaches by modulating...
Oncogenic Signaling Pathways in The Cancer Genome Atlas
2018年4月5日 · Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt.
Notch signaling pathway in cancer: from mechanistic insights to ...
2024年5月27日 · Accumulating evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer types. Dysregulation of this pathway promotes...
Signal Pathways in Cancer - PMC
In this Special Issue, a total of six contributions (three original articles and three reviews) are included, providing new information about the interaction between cancer cells and the TME and facilitating a better understanding of signal pathways in cancer.
Signal Transduction Pathways in Breast Cancer: The Important …
Modifications in various cell signalling pathways promote tumour cell proliferation, progression, and survival. The PI3K/Akt/mTOR pathway is an example of that, and it is involved in growth, proliferation, survival, motility, metabolism, and immune response regulation.
12 The signalling pathways in cancer - Oxford Academic
2019年4月1日 · Signalling pathways are made up by many different types of molecules which work together to control one or more cell functions in response to a given stimulus. The first part of the chapter will deal with the general principles, types of signals received by the cell, the receptors available, and how they transmit the signals to the downstream ...
- 某些结果已被删除