Succinate | C4H4O4-2 | CID 160419 - PubChem
网页Succinate(2-) is a dicarboxylic acid dianion resulting from the removal of a proton from both of the carboxy groups of succinic acid. It has a role as a human metabolite and a Saccharomyces cerevisiae metabolite.
Succinic acid - Wikipedia
网页Physical properties. Succinic acid is a white, odorless solid with a highly acidic taste. [5] . In an aqueous solution, succinic acid readily ionizes to form its conjugate base, succinate (/ ˈsʌksɪneɪt /). As a diprotic acid, succinic acid undergoes two successive deprotonation reactions: (CH 2) 2 (CO 2 H) 2 → (CH 2) 2 (CO 2 H) (CO 2) − + H +.
Why succinate? Physiological regulation by a mitochondrial
网页2022年4月28日 · Succinate, by equilibrating with the CoQ pool, enables the status of this central bioenergetic parameter to be communicated from mitochondria to the rest of the cell, into the circulation and to...
Succinate metabolism: a promising therapeutic target for …
网页2023年9月22日 · Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA) cycle and functions as a substrate for succinate dehydrogenase (SDH), thereby contributing to energy production in …
Succinate: a metabolic signal in inflammation - PubMed
网页Succinate is an intermediate of the tricarboxylic acid (TCA) cycle, and plays a crucial role in adenosine triphosphate (ATP) generation in mitochondria. Recently, new roles for succinate outside metabolism have emerged.
Succinate: a metabolic signal in inflammation - Cell Press
网页2013年12月19日 · Succinylation is a new post-translational modification that affects enzyme function. Abstract. Succinate is an intermediate of the tricarboxylic acid (TCA) cycle, and plays a crucial role in adenosine triphosphate (ATP) generation in mitochondria. Recently, new roles for succinate outside metabolism have emerged.
Succinate Is an Inflammation-Induced Immunoregulatory …
网页2020年9月15日 · The Krebs cycle metabolite succinate is one of the most well-described immunometabolites in macrophages. Succinate is synthesized within the mitochondrial matrix and is the ligand for electron transport chain (ETC) complex II, supplying ATP synthase electrons to drive ETC through oxidation to fumarate.
Rethinking succinate: an unexpected hormone-like metabolite in …
网页2021年9月1日 · Succinate is a pleiotropic signaling metabolite produced by both host and microbiota that acts akin to hormones and cytokines by engaging succinate receptor 1 (SUCNR1). As an integrative hub of inflammatory response in macrophages, perturbations of the succinate–SUCNR1 axis might cause dysfunction of key metabolic tissues.
Succinate is an inflammatory signal that induces IL-1β ... - Nature
网页2013年3月24日 · Succinate is identified as a metabolite in innate immune signalling, which leads to enhanced interleukin-1β production during inflammation. The bacterial endotoxin lipopolysaccharide activates ...
Succinate: a metabolic signal in inflammation - ScienceDirect
网页2014年5月1日 · Succinylation is a new post-translational modification that affects enzyme function. Succinate is an intermediate of the tricarboxylic acid (TCA) cycle, and plays a crucial role in adenosine triphosphate (ATP) generation in mitochondria. Recently, new roles for succinate outside metabolism have emerged.
- 某些结果已被删除