The C Terminus of the Herpes Simplex Virus UL25 Protein Is
Jul 12, 2017 · The significance of our research is in identifying pUL25 as a key viral factor for genome uncoating. pUL25 is found at each of the capsid vertices as part of the capsid vertex-specific component and implicates the importance of …
Role of the UL25 protein in herpes simplex virus DNA encapsidation
Oct 8, 2020 · The herpes simplex virus protein UL25 attaches to the external vertices of herpes simplex virus type 1 capsids and is required for the stable packaging of viral DNA. To define regions of the protein important for viral replication and capsid attachment, the 580-amino-acid UL25 open reading frame was ….
Structure of the herpes simplex virus type 2 C-capsid with capsid ...
Sep 10, 2018 · The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding...
The UL25 Gene Product of Herpes Simplex Virus Type 1 Is …
Apr 30, 2008 · Given the likely flexible architecture of UL25 and its position on the outside of the capsid, it is probable that UL25 is either a novel herpesviral protein or one that has evolved considerably to adapt to its eukaryotic environment, taking on new roles.
Labeling and Localization of the Herpes Simplex Virus Capsid …
Mar 26, 2010 · The herpes simplex virus type 1 UL25 protein is one of seven viral proteins that are required for DNA cleavage and packaging. Together with UL17, UL25 forms part of an elongated molecule referred to as the C-capsid-specific component (CCSC). Five copies of the CCSC are located at each of the capsid vertices on DNA-containing capsids.
Virus-derived peptide inhibitors of the herpes simplex virus …
Feb 18, 2021 · Here, we have identified peptides, derived from the capsid protein UL25, that are capable of inhibiting the membrane-budding activity of the NEC from herpes simplex virus type 1 in vitro. We show...
Residues of the UL25 Protein of Herpes Simplex Virus That Are …
UL25 is a capsid-associated protein that is required for successful secondary cleavage of viral genomes from the replicated concatemer and for retention of packaged DNA inside the HSV-1 capsid. In this paper, we describe a mutational analysis of the capsid-binding domain of UL25, located within its N-terminal 50 amino acids.
Herpes simplex virus capsid structure: DNA packaging protein UL25 …
UL25 is one of seven herpes simplex virus-encoded proteins involved specifically in DNA encapsidation. Its role appears to be to stabilize the capsid so that DNA is prevented from escaping once it has entered. To clarify the function of UL25, we have examined capsids with the goal of defining where it is located.
Role of the UL25 Gene Product in Packaging DNA into the Herpes …
Jul 3, 2000 · UL25 is incorporated at an early stage of capsid assembly and then waits for viral DNA to be packaged. To complete the packaging process, the UL25 may anchor the DNA to the vertex that initiated DNA packaging. Thus, the UL25 …
UL25 - snorkellifts.com
The Snorkel UL25 push-around mast lift is a lightweight and low cost indoor work platform. Designed with a small footprint and outriggers as standard, one person can easily set up and operate the UL25 for quick access.