Zolpidem - StatPearls - NCBI Bookshelf
网页2024年2月29日 · Zolpidem is a non-benzodiazepine hypnotic agent that works as a gamma-aminobutyric acid (GABA), a type of receptor chloride channel modulator/agonist that increases GABA inhibitory effects leading to sedation.
Zolpidem: Uses, Interactions, Mechanism of Action - DrugBank …
网页Zolpidem, the active moiety of zolpidem tartrate, is a hypnotic substance with a chemical structure that is not related to the structure benzodiazepines, barbiturates, pyrrolopyrazines, pyrazolopyrimidines or other drugs exerting hypnotic effects.
Zolpidem - Wikipedia
网页Zolpidem is a nonbenzodiazepine, or Z-drug, which acts as a sedative and hypnotic. [11] [20] Zolpidem is a GABA A receptor agonist of the imidazopyridine class. [11] It works by increasing GABA effects in the central nervous system by binding to GABA A receptors at the same location as benzodiazepines. [11] It generally has a half-life of two ...
Mechanism of action of the hypnotic zolpidem in vivo
网页Zolpidem is a widely used hypnotic agent acting at the GABA A receptor benzodiazepine site. On recombinant receptors, zolpidem displays a high affinity to α1-GABA A receptors, an intermediate affinity to α 2 - and α 3-GABA A receptors and …
Zolpidem | Description, Mechanism of Action, Uses, & Side Effects ...
网页2024年9月23日 · zolpidem, sedative-hypnotic drug used in the treatment of insomnia. Zolpidem decreases the excitability of neurons in the central nervous system, which has a calming effect on the brain that helps patients fall asleep and …
Zolpidem: Dosage, Mechanism/Onset of Action, Half-Life
网页2020年2月10日 · Last updated January 31, 2020. Includes Zolpidem indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.
Zolpidem: Efficacy and Side Effects for Insomnia - PMC
网页2021年6月18日 · Zolpidem is a non-benzodiazepine compound that shows a rapid-onset, short-duration hypnotic effect by binding to benzodiazepine receptors, particularly in the cerebellum, indicating a stronger binding preference for BZ(ω) receptors.
The Pharmacology and Mechanism of Action of Zolpidem
网页2006年6月7日 · The Pharmacology and Mechanism of Action of Zolpidem. David J. Sanger, Henri Depoortere. , First published: 07 June 2006. https://doi.org/10.1111/j.1527-3458.1998.tb00074.x. Citations: 49.
Zolpidem - PubMed
网页2024年2月29日 · Zolpidem is a non-benzodiazepine receptor modulator that is primarily indicated for the short-term alleviation of insomnia, particularly in individuals with sleep initiation challenges. This activity discusses zolpidem and its effectiveness in alleviating sleep latency duration and curtailing noctur …
The Pharmacology and Mechanism of Action of Zolpidem
网页The Pharmacology and Mechanism of Action of Zolpidem CNS Drug Rev. 1998 Dec;4(4):323-340. doi: 10.1111/j.1527-3458.1998.tb00074.x. Authors David J Sanger 1 , Henri Depoortere 1 Affiliation 1 Synthélabo Recherche, Bagneux, France. PMID: 29200233 DOI: 10.1111/j.1527-3458.1998 ...