Adduct - Wikipedia
In chemistry, an adduct (from Latin adductus 'drawn toward'; alternatively, a contraction of "addition product") is a product of a direct addition of two or more distinct molecules, resulting in a single reaction product containing all atoms of all components. [1]
DNA adduct - Wikipedia
In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could lead to the development of cancerous cells, or carcinogenesis. DNA adducts in scientific experiments are used as biomarkers of exposure. They are especially useful in quantifying an organism's exposure to a carcinogen. [1] .
DNA Adducts: formation, biological effects, and new …
Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In addition, reactive intermediates can be generated in the body …
DNA Adduct - an overview | ScienceDirect Topics
DNA Adduct. In subject area: Neuroscience. A DNA adduct is a piece of DNA that is chemically bonded to a cancer-causing substance. It is used as a biomarker to measure exposure to genotoxins and can indicate the potential risk of a chemical to cause cancer or mutations.
DNA adducts: Formation, biological effects, and new ... - PubMed
In this review article, we highlight the formation and biological effects of DNA adducts, and highlight our advances in human biomonitoring by mass spectrometric analysis of formalin-fixed paraffin-embedded tissues, untapped biospecimens …
Definition of adduct - Chemistry Dictionary
What is an Adduct? An adduct is a chemical species AB, each molecular entity of which is formed by direct combination of two separate molecular entities A and B in such a way that there is change in connectivity, but no loss, of atoms within the moieties A and B. Stoichiometries other than 1:1 are also possible, e.g. a bis-adduct (2:1).
Adducts | Facts, Summary & Definition | Chemistry Revision
An adduct is a product formed by an addition reaction. Adducts can only be formed from reactants which have multiple bonds, such as alkenes and carbonyl groups. Adducts can be formed through two types of addition reaction: electrophilic and nucleophilic. Adducts often form between Lewis acids and Lewis bases.
DNA Adduct - an overview | ScienceDirect Topics
In molecular genetics, a DNA adduct is a piece of DNA covalently bonded to a (cancer-causing) chemical. This process could be the start of a cancerous cell or carcinogenesis. DNA adducts in scientific experiments are used as biomarkers of exposure (La et al., 1996).
DNA adducts: Formation, biological effects, and new …
2018年6月11日 · In this review article, we highlight the formation and biological effects of DNA adducts, and highlight our advances in human biomonitoring by mass spectrometric analysis of formalin-fixed paraffin-embedded tissues, untapped biospecimens for carcinogen DNA adduct biomarker research.
DNA adducts-chemical addons - PMC - PubMed Central (PMC)
DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication.