Pimagedine - Wikipedia
Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug. [1] Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase.
Aminoguanidine - an overview | ScienceDirect Topics
Aminoguanidine reacts not only extensively with Amadori carbonyl groups of glycated proteins, but also with dicarbonyl compounds such as methylglyoxal, glyoxal, and 3-deoxyglucosone. Aminoguanidine is a prototype therapeutic agent for the inhibition of AGE formation.
Aminoguanidine | CH6N4 | CID 2146 - PubChem
2021年10月14日 · Aminoguanidine is a one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and an EC 1.14.13.39 ( nitric oxide synthase) inhibitor.
Aminoguanidine - an overview | ScienceDirect Topics
Aminoguanidine (also called pimagedine) is a nucleophilic hydrazine compound and has received the most attention as a potential anti-glycation drug [77]. Initially, it was thought that aminoguanidine prevented AGE formation by blocking carbonyl groups on Amadori products although it is now known to react with carbonyl groups from reducing ...
The chemistry of aminoguanidine derivatives – preparation, …
2015年11月1日 · Aminoguanidine, a bifunctional molecule, is a hydrazine derivative and, hence, is expected to form salts similar to those of hydrazine. Aminoguanidine acts as a diacidic base and forms AmgH + [aminoguanidinium (+1)] and AmgH 2 + [aminoguanidinium (+2)] salts with minerals, or carboxylic acids, or both.
Chelation: A Fundamental Mechanism of Action of AGE …
2012年2月13日 · While aminoguanidine is the prototype AGE inhibitor, its proposed mechanism of action is based completely on model chemical studies in vitro.
Biological effects of aminoguanidine: an update - PubMed
Aminoguanidine (AMG) was prepared more than 100 years ago. During the last 10 years two important effects of AMG have been discovered which have made this molecule attract a lot of interest.
Advanced Glycation End Products in Health and Disease - PMC
Aminoguanidine treatment increases vascular elasticity and decreases vascular permeability in diabetic rat models and may exert a mitigating effect on diabetic cardiomyopathy and diabetic heart failure [103,109].
Aminoguanidine Prevents Diabetes-Induced Arterial Wall
Aminoguanidine, a nucleophilic hydrazine compound, prevented both the formation of fluorescent advanced nonenzymatic glycosylation products and the formation of glucose-derived collagen cross-links in vitro.
Novel Aminoguanidine Hydrazone Analogues: From Potential …
2021年11月26日 · Aminoguanidine (AG; hydrazinecarboximidamide) inhibits selectively inducible nitric oxide synthase and scavenges reactive oxygen species, thus being antioxidant agent protecting various cells and tissues from oxidative stress.
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