Calcineurin - Wikipedia
网页Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). [2] It activates the T cells of the immune system and can be blocked by drugs.
Calcineurin in development and disease - PMC - National Center …
网页2021年3月15日 · Calcineurin (CaN) is a unique calcium (Ca 2+) and calmodulin (CaM)-dependent serine/threonine phosphatase that becomes activated in the presence of increased intracellular Ca 2+ level. CaN then functions to dephosphorylate target substrates including various transcription factors, receptors, and channels.
Calcineurin: form and function - PubMed
网页This review provides a comprehensive examination of the biological roles of calcineurin and reviews aspects related to its structure and catalytic mechanism.
Calcineurin Inhibitors - StatPearls - NCBI Bookshelf
网页2023年11月12日 · Calcineurin inhibitors (CNIs) are a class of immunosuppressants utilized to effectively manage various autoimmune disorders, including, but not limited to, lupus nephritis, idiopathic inflammatory myositis, interstitial lung disease, and atopic dermatitis.
Calcineurin | Cell Communication and Signaling | Full Text
网页2020年8月28日 · Calcineurin is activated by increases in intracellular calcium concentrations, a process that requires the calcium sensing protein calmodulin binding to an intrinsically disordered regulatory domain in the phosphatase.
Calcineurin Is a Universal Regulator of Vessel Function—Focus on ...
网页2023年9月13日 · Calcineurin, a serine/threonine phosphatase regulating transcription factors like NFaT and CREB, is well known for its immune modulatory effects and role in cardiac hypertrophy.
Calcineurin - PubMed
网页2020年8月28日 · Calcineurin is activated by increases in intracellular calcium concentrations, a process that requires the calcium sensing protein calmodulin binding to an intrinsically disordered regulatory domain in the phosphatase. Despite having been studied for around four decades, the activation of calcineurin is not fully understood.
Calcineurin - an overview | ScienceDirect Topics
网页Calcineurin is a calmodulin-dependent serine/threonine phosphatase, consists of the catalytic subunit calcineurin A and a regulatory subunit, calcineurin B. In mammals, there are three known isoforms of calcineurin A, CnAα, CnAβ, and CnAγ, and two isoforms of calcineurin B, CnB1, and CnB2.
Calcineurin: Current Biology - Cell Press
网页2005年6月21日 · Calcineurin is a phosphoprotein serine/threonine phosphatase, activated physiologically by Ca 2+ –calmodulin. In plain language, calcineurin couples intracellular Ca 2+ to dephosphorylation of selected substrates. The biological consequences are diverse and depend on the cellular context.
Calcineurin: Form and Function | Physiological Reviews
网页2000年1月10日 · Calcineurin is a eukaryotic Ca2+- and calmodulin-dependent serine/threonine protein phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A, which contains an act...
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