Multifunctional Role of Chymase in Acute and Chronic Tissue …
2018年1月19日 · Chymase is the most efficient Ang II (angiotensin II)–forming enzyme in the human body and has been implicated in a wide variety of human diseases that also implicate its many other protease actions.
Chymase - an overview | ScienceDirect Topics
Chymase is a chymotrypsin-like neutral protease that is found in a specific subset of human mast cells. It has the ability to cleave matrix components and activate enzymes involved in matrix remodeling. Additionally, chymase can activate angiotensin I, leading to the independent activation of angiotensin II.
Chymase: its pathophysiological roles and inhibitors - PubMed
Chymase is a chymotrypsin-type serine protease mainly localized in mast cells (MCs). Human, primate, and dog chymase generate angiotensin II (Ang II) from Ang I, while mouse and rat chymases degrade Ang II.
Chymase - an overview | ScienceDirect Topics
Chymase is a serine protease present in mast cells, cardiac fibroblasts and endothelial cells that mediates the production of angiotensin-II (Ang II) via an alternative ACE-independent pathway [141]. Chymase is released into the interstitium in response to tissue injury and inflammation.
Multifunctional Role of Chymase in Acute and Chronic Tissue
2018年1月19日 · Chymase is the most efficient Ang II (angiotensin II)-forming enzyme in the human body and has been implicated in a wide variety of human diseases that also implicate its many other protease actions.
Vascular chymase: pathophysiological role and therapeutic …
2004年3月1日 · Chymase is a chymotrypsin-like serine protease, stored in a macromolecular complex with heparin proteoglycan within the secretory granules of mast cells. On release, chymase remains complexed and binds to the extracellular matrix, and continues to …
Chymase: the other ACE? - PMC - National Center for …
2009年11月18日 · This study explores the hypothesis that intrarenal angiotensin II can be generated from angiotensinogen by either of two pathways: a conventional ACE-dependent mechanism, and alternatively by an ACE-independent pathway, likely mediated by chymase.
Mast cell chymase: morphofunctional characteristics
2019年8月8日 · In this review, we discussed the current state of knowledge about mast cell chymase as one of the mast cell secretome proteases. Main issues of the reviewed publications are highlighted with our microscopic images of mast cell chymase visualized using immunohistochemical staining.
Chymase - an overview | ScienceDirect Topics
Chymase is a chymotrypsin-like serine protease that is stored in and released from mast cells, within the immune system. 71e,79 Inhibitors of this enzyme have therapeutic potential in the treatment of immune-mediated inflammatory disorders, such as asthma, and cardiovascular disorders, such as atherosclerosis. 79b,80 Akahoshi et al. described a ...
Multifunctional Role of Chymase in Acute and Chronic Tissue …
2018年1月1日 · Chymase is the most efficient angiotensin II-forming enzyme in the human body and has been implicated in a wide variety of human diseases that also implicate its many other protease actions.
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