A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions …
2023年1月23日 · Here we report that PloI4, a β-barrel-fold protein homologous to the exo-selective 4 + 2 cyclase that functions in the biosynthesis of pyrroindomycins, catalyses competitive 2 + 2 and 4 + 2 ...
Discovery of the cryptic function of terpene cyclases as aromatic ...
2020年8月7日 · Here, we report that the catalytic activity of the terpene cyclases AaTPS and FgGS can be switched from cyclase to aromatic prenyltransferase at basic pH to generate prenylindoles.
Cyclase - an overview | ScienceDirect Topics
Cyclase. As their name implies, CDNs are heterocyclic compounds synthesized by cyclases or nucleotidyltransferases (NTases) through the cyclization of two ribonucleoside triphosphate moieties via two “canonical” (3′,5′) and/or “noncanonical” (2′,5′) phosphodiester linkages.
Biochemistry, Guanylate Cyclase - StatPearls - NCBI Bookshelf
2023年7月30日 · Guanylyl cyclase (also known as guanylate cyclase) is an enzyme that catalyzes the synthesis of cyclic guanosine 3′,5′-monophosphate (cGMP) from guanosine 5' triphosphate (GTP). Guanylyl cyclase exists in both a membrane-bound and soluble form in the cell.
Structure and function of adenylyl cyclases, key enzymes in …
2020年8月1日 · The adenylyl cyclases (ACs) catalyze the production of the ubiquitous second messenger, cAMP, which in turns acts on a number of effectors and thus regulates a plethora of cellular functions.
Cyclase Definition & Meaning - Merriam-Webster
2023年11月6日 · The meaning of CYCLASE is an enzyme (such as adenylate cyclase) that catalyzes cyclization of a compound.
Substrate interactions guide cyclase engineering and lasso …
2024年9月11日 · Here the authors identify key molecular interactions that guide lasso peptide folding and cyclase substrate tolerance to inform cyclase engineering for expanded lasso peptide diversity.
Structural and Chemical Biology of Terpenoid Cyclases
2017年8月25日 · The role of the terpenoid cyclase as a template for catalysis is paramount to its function, and protein engineering can be used to reprogram the cyclization cascade to generate alternative and commercially important products.
Bacterial diguanylate cyclases: structure, function and mechanism …
This review discusses the structure and reaction of individual diguanylate cyclase enzymes with a focus on new directions in c-di-GMP research. Specific attention is made on the molecular mechanisms that control bacterial exopolysaccharide biofilm formation and aerobic granules.
Structural and Chemical Biology of Terpenoid Cyclases
Here, I review key advances in terpenoid cyclase structural and chemical biology, focusing mainly on terpenoid cyclases and related prenyltransferases for which X-ray crystal structures have informed and advanced our understanding of enzyme structure and function.
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