N-Nitrosodiethylamine - Wikipedia
N-Nitrosodiethylamine (NDEA) is an organic compound with the formula Et 2 NNO (Et = C 2 H 5). A member of the nitrosamines, it is a light-sensitive, volatile, clear yellow oil that is soluble in water, lipids, and other organic solvents. It has an amine or aromatic odor.
Diethylnitrosamine (DEN)-induced carcinogenic liver injury ...
2015年4月5日 · The parenteral or oral administration of the smallest quantities of diethylnitrosamine (DEN) or dimethylnitrosamine (DMN) results in severe liver damage. Most prominent are intense neutrophilic infiltration, extensive centrilobular haemorrhagic necrosis, bile duct proliferation, fibrosis, and bridging necrosis that ends in hepatocarcinogenesis.
Diethylnitrosamine - an overview | ScienceDirect Topics
Main technical features (chemicals, rodent species/strains, and endpoint lesions) and cancer hallmarks/emerging characteristics involved in the pathogenesis of diethylnitrosamine (DEN)-based hepatocarcinogenesis models.
Diethylnitrosamine Increases Proliferation in Early Stages ...
2018年4月23日 · Diethylnitrosamine (DEN) induces hepatocarcinogenesis, increasing mitotic hepatocytes and leading to chronic inflammation. In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment.
Mouse models of hepatocellular carcinoma - Nature
2018年6月14日 · Diethylnitrosamine (DEN) is a carcinogen that has been used to induce HCC in mice for several decades, showing progression of disease from basophilic foci, hyperplasic nodules, hepatocellular ...
Diethylnitrosamine (DEN) induces irreversible hepatocellular ...
2009年12月15日 · Diethylnitrosamine (DEN) is a representative chemical carcinogen with the potential to cause tumors in various organs, including the liver, skin, gastrointestinal tract, and respiratory system. Specifically in HCC, DEN is a complete carcinogen. Many lines of evidence have demonstrated a relationship between carcinogenesis and cell cycle regulation.
Diethylnitrosamine-induced liver tumorigenesis in mice
Animal models of HCC are particularly useful to better understand molecular events underlying liver tumorigenesis. To this end, chemical carcinogenesis protocols based on the injection of genotoxic compounds such as diethylnitrosamine (DEN) are widely used to model liver tumorigenesis in rodents.
Sequential analysis of diethylnitrosamine-induced …
2011年12月15日 · In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes.
Resistance against the development of diethylnitrosamine …
One of the most used models is diethylnitrosamine (DEN)-induced HCC in C3H mice that produce multiple tumor foci per liver that gradually increase over time and progress to trabecular hepatocellular metastatic carcinomas. This model has histology, genetic signature, and sex disparity similar to human HCCs .
Diethylnitrosamine Induction of Hepatocarcinogenesis in Mice
2024年2月6日 · Diethylnitrosamine (DEN) is a chemical hepatocarcinogenic agent that triggers a large array of oncogenic mutations after a single injection. Initiated hepatocytes subsequently undergo clonal expansion within a proliferative environment, rendering the DEN model a comprehensive carcinogen.