Dihydrofolic acid - Wikipedia
网页Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B 9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. [1]
Dihydrofolate reductase - Wikipedia
网页Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in one-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene.
Folate: Uses, Benefits, Side Effects, Dosage, Precautions
网页2022年8月13日 · Folate is the natural form of vitamin B9 that the body needs to maintain its genetic building blocks, DNA and RNA. However, folate is water-soluble, meaning the body does not store it, and you need to replenish it regularly through your diet.
Folate metabolism: a re-emerging therapeutic target in ... - Nature
网页2021年3月11日 · Folate metabolism, considered the core of a broader set of transformations known as one-carbon (1C) metabolism, allows the transfer of 1C units for biosynthetic purposes such as de novo synthesis...
Dihydrofolate Reductase Gene Variations in Susceptibility to …
网页Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent enzymes and is thus essential for DNA synthesis and methylation.
About Folic Acid | Folic Acid | CDC - Centers for Disease Control …
网页Folic acid is a form of folate, a B vitamin that helps your body make new cells. All people capable of becoming pregnant should get 400 mcg of folic acid every day. Getting 400 micrograms of folic acid daily can help prevent a type …
Folate Metabolism Regulates Oligodendrocyte Survival and
网页2017年5月11日 · Dihydrofolate reductase (DHFR) is a key enzyme to regulate folate metabolism, however folate/DHFR activity in oligodendrocyte development has not been fully understood.
Structure-guided functional studies of plasmid-encoded dihydrofolate …
网页2022年5月13日 · Two plasmid-encoded dihydrofolate reductase (DHFR) isoforms, DfrA1 and DfrA5, that give rise to high levels of resistance in Gram-negative bacteria were structurally and biochemically ...
Folic Acid Antagonists: Antimicrobial and Immunomodulating …
网页2019年10月9日 · Dihydrofolate reductase (DHFR, EC 1.5.1.3) is the most studied enzyme in folate pathway due to its relevance in the maintenance of the cycle. Reduction of dihydrofolate (DHF) ensures an intracellular pool of different THF derivatives that are used in various one-carbon transference reactions and biosynthetic processes.
Folate - Health Professional Fact Sheet - Office of Dietary …
网页Before entering the bloodstream, the enzyme dihydrofolate reductase reduces the monoglutamate form to THF and converts it to either methyl or formyl forms . The main form of folate in plasma is 5-MTHF.